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Genistein Implications in Radiotherapy: Kill Two Birds with One Stone.
Molecules
January 2025
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
More than 70% of cancer patients receive radiotherapy during their treatment, with consequent various side effects on normal cells due to high ionizing radiation doses despite tumor shrinkage. To date, many radioprotectors and radiosensitizers have been investigated in preclinical studies, but their use has been hampered by the high toxicity to normal cells or poor tumor radiosensitization effects. Genistein is a naturally occurring isoflavone found in soy products.
View Article and Find Full Text PDFRadiation-Resistant Bacteria Deinococcus radiodurans-Derived Extracellular Vesicles as Potential Radioprotectors.
Adv Healthc Mater
December 2024
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do, 56212, Republic of Korea.
The increasing use of radiation presents a risk of radiation exposure, making the development of radioprotectors necessary. In the previous study, it is investigated that Deinococcus radiodurans (R1-EVs) exert the antioxidative properties. However, the radioprotective activity of R1-EVs remains unclear.
View Article and Find Full Text PDFOpuntia ficus indica cladode extract inhibit DNA double-strand breaks and locally multiply damaged sites induced by gamma radiation.
J Genet Eng Biotechnol
December 2024
Faculty of Applied Medical Science Al Ula branch, Department of Nursing, Taibah University, Kingdom of Saudi Arabia; Department of Nuclear Medicine and Radiobiology, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada; Laboratory of Biochemistry and Molecular Biology, Faculty of Sciences of Bizerte, Carthage University, Tunisia. Electronic address:
Unlabelled: It is beyond doubt that radiotherapy is extremely effective in treating a wide variety of cancers. The sensitivity of the surrounding normal tissues limits the amount of radiation administered to the tumor. There is an urgent need to develop a treatment that combines pharmacological treatment with ionizing radiation (IR) specifically designed to specifically target cancer cells while protecting the surrounding normal tissue, resulting in an increase in the efficacy of the cancer treatment.
View Article and Find Full Text PDFA Novel Antioxidant Peptide Mitigates Oxidative Stress in Irradiated CHO-K1 Cells.
Microorganisms
October 2024
Radiation Biotechnology Division, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea.
Reactive oxygen species (ROS), byproducts of cellular metabolism and environmental factors, are linked to diseases like cancer and aging. Antioxidant peptides (AOPs) have emerged as effective countermeasures against ROS-induced damage. The genus is well known for its extraordinary resilience to ionizing radiation (IR) and possesses complex antioxidant systems designed to neutralize ROS generated by IR.
View Article and Find Full Text PDFCurcumin's Radioprotective Effects on Zebrafish Embryos.
Antioxidants (Basel)
October 2024
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld. 16, 90128 Palermo, Italy.
Radiation modifiers are largely studied for their contribution to enlarging the treatment window. Curcumin is already known for its antioxidant properties; however, its role as a radioprotector in preclinical studies is affected by the well-known low absorption and bioavailability of curcumin. In this study, curcumin's radioprotection ability has been evaluated in zebrafish larvae, by taking advantage of quantifying curcumin absorption and evaluating its fluorescence in transparent embryos.
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