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Decoding the rhythmic representation and communication of visual contents.
Trends Neurosci
January 2025
Neural Computation Group, Department of Mathematics and Computer Science, Physics, Geography, Justus-Liebig-Universität Gießen, Gießen 35392, Germany; Center for Mind, Brain and Behavior (CMBB), Philipps-Universität Marburg, Justus-Liebig-Universität Gießen & Technische Universität Darmstadt, Marburg 35032, Germany. Electronic address:
Rhythmic neural activity is considered essential for adaptively modulating responses in the visual system. In this opinion article we posit that visual brain rhythms also serve a key function in the representation and communication of visual contents. Collating a set of recent studies that used multivariate decoding methods on rhythmic brain signals, we highlight such rhythmic content representations in visual perception, imagery, and prediction.
View Article and Find Full Text PDFResonance-Induced Therapeutic Technique for Skin Cancer Cells.
Ultrasound Med Biol
January 2025
Institute of Biomedical Technologies, Auckland University of Technology, Auckland City, 1010, Auckland, New Zealand. Electronic address:
Objective: This study aims to evaluate the viability of a hypothesis for selective targeting of skin cancer cells by exploiting the spectral gap with healthy cells using analytical and numerical simulation.
Methods: The spectral gap was first identified using a viscoelastic dynamic model, with the physical and mechanical properties of healthy and cancerous skin cells deduced from previous experimental studies conducted on cell lines. The outcome of the analytical simulation was verified numerically using modal and harmonic analysis.
Development of TAR-200: A novel targeted releasing system designed to provide sustained delivery of gemcitabine for patients with bladder cancer.
Urol Oncol
January 2025
Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan, Italy; Department of Medical Oncology, IRCCS San Raffaele University, Milan, Italy.
Treatment options for recurrent high-risk non-muscle-invasive bladder cancer (HR NMIBC) and muscle-invasive bladder cancer (MIBC) are limited, highlighting a need for clinically effective, accessible, and better-tolerated alternatives. In this review we examine the clinical development program of TAR-200, a novel targeted releasing system designed to provide sustained intravesical delivery of gemcitabine to address the needs of patients with NMIBC and of those with MIBC. We describe the concept and design of TAR-200 and the clinical development of this gemcitabine intravesical system in the SunRISe portfolio of studies.
View Article and Find Full Text PDFImpact of Fli1 deletion on B cell populations: A focus on age-associated B cells and transcriptional dynamics.
J Dermatol Sci
December 2024
Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan; Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:
Background: Altered Fli1 expression is associated with various autoimmune diseases, yet its impact on B cells remains unexplored.
Objective: This study investigated the direct effects of Fli1 depletion on B cell populations, focusing on age-associated B cells (ABCs).
Methods: Splenocytes of Fli1 BcKO (Cd19-Cre; Fli1) and Cd19-Cre mice were analyzed flow cytometrically.
Unfolded protein response modulates Tyrosinase levels and melanin production during melanogenesis.
J Dermatol Sci
January 2025
Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan; Department of Frontier Science and Interdisciplinary Research, Faculty of Medicine, Kanazawa University, Ishikawa, Japan. Electronic address:
Background: Melanocytes protect the body from ultraviolet radiation by synthesizing melanin. Tyrosinase, a key enzyme in melanin production, accumulates in the endoplasmic reticulum (ER) during melanin synthesis, potentially causing ER stress. However, regulating ER function for melanin synthesis has been less studied than controlling Tyrosinase activity.
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