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Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches.
Sci Rep
January 2025
Department of Pharmacognosy, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan.
Clozapine is a potent serotonin receptor antagonist and commonly used for the treatment of Schizophrenia. The study aimed to develop and optimize the transdermal matrix patch of clozapine. A 3-level, 3-factor Central Composite Design was applied to examine and validate the impact of various formulation variables, Eudragit, PEG, and oleic acid on in vitro drug release, flux, and tensile strength (TS).
View Article and Find Full Text PDFNeuropharmacological potential of Mimosa tenuiflora in adult zebrafish: An integrated approach to GABAergic and serotonergic neuromodulation.
Behav Brain Res
January 2025
Experimental Biology Center, University of Fortaleza, Av. Washington Soares, 1321, Fortaleza, Ceará, Brazil; Laboratory of Bioprospection of Natural Products and Biotechnology, Department of Chemistry, CECITEC/UECE - Center for Education, Science and Technology of the Inhamuns Region. R. Seis, 15 - Bezerra de Sousa, Tauá, Ceará, Brazil. Electronic address:
Mimosa tenuiflora ("jurema-preta") is traditionally used in folk medicine for various diseases. The study investigated the neuropharmacological potential of Mimosa tenuiflora bark fraction (FATEM) in adult zebrafish. This included the acute toxicity (LC50) of FATEM (0.
View Article and Find Full Text PDFAmelioration of cognition by hesperidin-conjugated cobalt oxide nanoparticles.
Sci Rep
December 2024
School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.
Diabetes mellitus is one of the metabolic syndromes that is associated with cognitive deficit, dementia, and Alzheimer's disease (AD) like pathology due to impaired insulin-signalling in the brain, oxidative stress and mitochondrial dysfunction. Nanotechnology is one of the most promising techniques for targeting the brain. However, the toxicity of metal nanoparticles is one of the biggest challenges to be studied.
View Article and Find Full Text PDFGC-MS Analysis, Neuropharmacological, and Antidiarrheal Activities of the Acetone Extract of Najas gracillima Seaweed: In Vivo and In Silico Study.
Chem Biodivers
December 2024
De, partment of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong, Bangladesh.
Najas gracillima, a marine seaweed found in North America and Asia, was investigated for its neuropharmacological and antidiarrheal properties. Acetone extracts of N. gracillima (ANG) were analyzed using both in vivo and in silico methods.
View Article and Find Full Text PDFA comprehensive analysis of propofol abuse and addiction and neuropharmacological aspects: an updated review.
Korean J Anesthesiol
December 2024
Department of Medical Pharmacology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpaşa, İstanbul, Turkey.
This review aims to assess the existing studies on propofol, a relatively new intravenous anesthetic, related to its abuse and addictive potential and to explain the neurobiological and neuropharmacological aspects of propofol addiction. Several neurobiological factors related to complex processes in the brain influence propofol abuse and addiction. In this review, we assessed the literature regarding propofol abuse and addiction, including both experimental and clinical studies.
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