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Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival.
Cell Commun Signal
January 2025
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic adaptations upon acute loss of glucose metabolism. Here, we investigated a potent small molecule inhibitor to Class I glucose transporters, KL-11743, using glycolytic leukemia cell lines and patient-based model systems.
View Article and Find Full Text PDFCases abound in which nearly identical traits have appeared in distant species facing similar environments. These unmistakable examples of adaptive evolution offer opportunities to gain insight into their genetic origins and mechanisms through comparative analyses. Here, we present a novel comparative genomics approach to build genetic models that underlie the independent origins of convergent traits using evolutionary sparse learning.
View Article and Find Full Text PDFPopulation Pharmacokinetics of Telmisartan in Healthy Subjects and Hypertensive Patients.
Clin Pharmacokinet
January 2025
College of Pharmacy, Kyungsung University, 309, Suyeong-ro, Nam-gu, Busan, 48434, Republic of Korea.
Background And Objective: Telmisartan exhibits significant pharmacokinetic (PK) variability, but it remains unclear whether its PK profile is altered in hypertensive patients. This study aimed to characterize telmisartan PKs by conducting a meta-analysis and developing a pooled population PK model based on data from healthy subjects and hypertensive patients.
Methods: Relevant literature was identified by a systematic approach.
Chronic enrichment affects nitrogen removal in tidal freshwater river and estuarine creek sediments.
J Environ Qual
January 2025
Institute for the Environment, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Population growth in coastal areas increases nitrogen inputs to receiving waterways and degrades water quality. Wetland habitats, including floodplain forests and marshes, can be effective nitrogen sinks; however, little is known about the effects of chronic point source nutrient enrichment on sediment nitrogen removal in tidally influenced coastal systems. This study characterizes enrichment patterns in two tidal systems affected by wastewater treatment facility (WWTF) effluent and assesses the impact on habitat nitrogen removal via denitrification.
View Article and Find Full Text PDFFish Meal Replacement by Chicken By-Product Meal in Diet: Impacts on Growth and Feed Availability of Juvenile Rockfish (), and Economical Analysis.
Animals (Basel)
January 2025
Division of Convergence on Marine Science, Korea Maritime and Ocean University, Busan 49112, Republic of Korea.
A 56-day feeding experiment was carried out to evaluate the effects of substituting fish meal (FM) with chicken by-product meal (CBM) in diets on the growth and feed utilization of rockfish (). Six experimental diets were formulated to be isonitrogenous and isolipidic. The control (Con) diet included 55% FM.
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