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Characterizing Microbubble-Mediated Permeabilization in a Vessel-on-a-Chip Model.
Small
December 2024
Biomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Wytemaweg 80, Rotterdam, 3015 CN, The Netherlands.
Drug transport from blood to extravascular tissue can locally be achieved by increasing the vascular permeability through ultrasound-activated microbubbles. However, the mechanism remains unknown, including whether short and long cycles of ultrasound induce the same onset rate, spatial distribution, and amount of vascular permeability increase. Accurate models are necessary for insights into the mechanism so a microvessel-on-a-chip is developed with a membrane-free extravascular space.
View Article and Find Full Text PDFDeep phenotyping of pulmonary edema and pulmonary vascular permeability in COVID-19 ARDS.
Am J Physiol Lung Cell Mol Physiol
January 2025
Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Clinical monitoring of pulmonary edema due to vascular hyperpermeability in acute respiratory distress syndrome (ARDS) poses significant clinical challenges. Presently, no biological or radiological markers are available for quantifying pulmonary edema. Our aim was to phenotype pulmonary edema and pulmonary vascular permeability in patients with coronavirus disease 2019 (COVID-19) ARDS.
View Article and Find Full Text PDFRelieving the transfusion tissue traffic jam: a network model of radial transport in conifer needles.
New Phytol
December 2024
Department of Physics, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Characteristic of all conifer needles, the transfusion tissue mediates the radial transport of water and sugar between the endodermis and axial vasculature. Physical constraints imposed by the needle's linear geometry introduce two potential extravascular bottlenecks where the opposition of sugar and water flows may frustrate sugar export: one at the vascular access point and the other at the endodermis. We developed a network model of the transfusion tissue to explore how its structure and composition affect the delivery of sugars to the axial phloem.
View Article and Find Full Text PDFThe influence of sex, age, and body height on the pulmonary vascular permeability index - a prospective observational study.
Sci Rep
September 2024
Technical University of Munich, TUM School of Medicine and Health, Munich, Germany.
Article Synopsis
- The pulmonary vascular permeability index (PVPI) is a measure of lung water relative to blood volume, which becomes elevated in conditions like acute respiratory distress syndrome (ARDS) due to damage to lung membranes.
- A study involving 251 patients showed that women have significantly higher PVPI values than men, and that PVPI decreases with increasing age and height.
- The findings suggest that PVPI may be influenced by anthropometric factors, potentially leading to misclassification of abnormal PVPI readings, indicating the need for further research in this area.
Role of Alveolar-Arterial Difference in Estimation of Extravascular Lung Water in COVID-19-Related ARDS.
Respir Care
November 2024
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
Background: The dominant feature of COVID-19-associated ARDS is gas exchange impairment. Extravascular lung water index is a surrogate for lung edema and reflects the level of alveolocapillary disruption. The primary aim was the prediction of extravascular lung water index by the alveolar-arterial oxygen difference.
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