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The nucleosome reference frame and standard geometries for octasomes.
Biophys Rev
June 2024
Departments of Chemistry and Physics, Louisiana Tech University, 600 Dan Reneau Dr, Ruston, LA 71272 USA.
Unlabelled: There are over 533 nucleosome structures in the Research Collaboratory for Structural Bioinformatics (RCSB). Collectively, numerous variants and species are present, as are sub-nucleosomal and super-nucleosomal assemblies within the nucleosome family. The organization of the histones and DNA is highly conserved in all standard octasomes containing 145, 146, or 147 base pairs.
View Article and Find Full Text PDFProbing archaeal cell biology: exploring the use of dyes in the imaging of cells.
Front Microbiol
September 2023
Cell Biology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Article Synopsis
- Archaea play a vital role in ecological processes, but our understanding of their biology and diversity is limited compared to eukaryotes and bacteria.
- Extremophiles, which are a type of archaea, thrive in harsh conditions, complicating their study; however, advancements like live cell imaging and genetic tools have improved research on some mesophilic archaea.
- The study discusses various fluorescent markers used for imaging archaeal cells and presents both successful and unsuccessful methods while offering hope that some techniques may be applicable to other archaeal species.
Assessing in vivo the impact of gene context on transcription through DNA supercoiling.
Nucleic Acids Res
October 2023
Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, Université PSL, Paris, France.
Gene context can have significant impact on gene expression but is currently not integrated in quantitative models of gene regulation despite known biophysical principles and quantitative in vitro measurements. Conceptually, the simplest gene context consists of a single gene framed by two topological barriers, known as the twin transcriptional-loop model, which illustrates the interplay between transcription and DNA supercoiling. In vivo, DNA supercoiling is additionally modulated by topoisomerases, whose modus operandi remains to be quantified.
View Article and Find Full Text PDFMultifrequency Investigation of Single- and Double-Stranded DNA with Scalable Metamaterial-Based THz Biosensors.
Biosensors (Basel)
July 2022
Institute of High Frequency and Quantum Electronics HQE, University of Siegen, 57076 Siegen, Germany.
Due to the occurrence of THz-excited vibrational modes in biomacromolecules, the THz frequency range has been identified as particularly suitable for developing and applying new bioanalytical methods. We present a scalable THz metamaterial-based biosensor being utilized for the multifrequency investigation of single- and double-stranded DNA (ssDNA and dsDNA) samples. It is demonstrated that the metamaterial resonance frequency shift by the DNA's presence depends on frequency.
View Article and Find Full Text PDFMulti-Targeted Anticancer Activity of Imidazolate Phosphane Gold(I) Compounds by Inhibition of DHFR and TrxR in Breast Cancer Cells.
Front Chem
January 2021
School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
A class of phosphane gold(I) compounds, made of azoles and phosphane ligands, was evaluated for a screening on the regards of Breast Cancer cell panels (BC). The compounds possess N-Au-P or Cl-Au-P bonds around the central metal, and they differ for the presence of aprotic or protic polar groups in the azoles and/or the phosphane moieties to tune their hydrophilicity. Among the six candidates, only the compounds having the P-Au-N environment and not displaying neither the hydroxyl nor carboxyl groups in the ligands were found active.
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