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Combined CAR-T/HSCT approach in a patient with refractory acute lymphoblastic leukemia and cystic fibrosis.
Tumori
December 2024
Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Introduction: The association of acute lymphoblastic leukaemia (ALL) and cystic fibrosis (CF) is rare. We present the case of a paediatric patient affected by CF and refractory B-cell precursor (BCP) ALL, who was treated with combined chimeric antigen receptor T-cells (CAR-T) and allogeneic haematopoietic stem cell transplantation (HSCT).
Case Description: Autologous-CD19 targeting CAR-T allowed to achieve molecular remission and spare chemo-related toxicity.
Pulmonary veno-occlusive disease (PVOD) is a lethal variant of pulmonary hypertension. The degree of pulmonary arterial involvement varies. Here, we compare two PVOD patients who were transplanted at 8 years of age, whereof one is a homozygous mutation carrier.
View Article and Find Full Text PDFPosterior Spinal Cord Infarction Complicating a Bronchial Arterial Embolization.
Cureus
November 2024
Intensive Care Unit, Hospital Vila Franca de Xira, Vila Franca de Xira, PRT.
Massive hemoptysis is a life-threatening condition. Bronchial artery embolization (BAE) is an effective technique for controlling bleeding in cases of severe hemoptysis, with infrequent complications. While rare, spinal cord infarction is a serious potential complication of BAE.
View Article and Find Full Text PDFPulmonary veno-occlusive disease: A systematic review of risk factors, clinical presentation, diagnostic investigations, treatment outcomes and prognostic factors.
J Med Imaging Radiat Oncol
December 2024
Department of Cardiology, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.
Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension. We aimed to systematically evaluate published cases of PVOD to provide an overview of their clinical presentation, management and prognosis to assist early identification and treatment. We conducted a literature search of PubMed and Embase databases for adult cases of 'pulmonary veno-occlusive disease' and 'pulmonary capillary haemangiomatosis'.
View Article and Find Full Text PDFBurden of illness of non-hematopoietic stem cell transplant-related hepatic sinusoidal obstruction syndrome: A systematic review.
Heliyon
October 2024
Jazz Pharmaceuticals, Oxford, UK.
Background: Sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) is generally associated with hematopoietic cell transplant (HCT), but little is known about this condition outside the HCT setting. This systematic review examines the burden of illness and current management approaches in non-HCT SOS/VOD.
Methods: We searched Embase, Medline, and grey literature sources for non-HCT SOS/VOD studies published 2002-2023.
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