Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/211637b0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
mA RNA methylation regulates the fate of endogenous retroviruses.
Nature
March 2021
Institut Curie, PSL Research University, INSERM U934, CNRS UMR3215, Paris, France.
Endogenous retroviruses (ERVs) are abundant and heterogenous groups of integrated retroviral sequences that affect genome regulation and cell physiology throughout their RNA-centred life cycle. Failure to repress ERVs is associated with cancer, infertility, senescence and neurodegenerative diseases. Here, using an unbiased genome-scale CRISPR knockout screen in mouse embryonic stem cells, we identify mA RNA methylation as a way to restrict ERVs.
View Article and Find Full Text PDFInduction of Leptomeningeal Cells Modification Via Intracisternal Injection.
J Vis Exp
May 2020
Department of Cell and Molecular Biology, Karolinska Institute;
The protocol outlined here describes how to safely and manually inject solutions through the cisterna magna while eliminating the risk of damage to the underlying parenchyma. Previously published protocols recommend using straight needles that should be lowered to a maximum of 1-2 mm from the dural surface. The sudden drop in resistance once the dural membrane has been punctured makes it difficult to maintain the needle in a steady position.
View Article and Find Full Text PDFIntrathecal drug delivery in the era of nanomedicine.
Adv Drug Deliv Rev
September 2021
Vivian L. Smith Department of Neurosurgery, McGovern Medical School/University of Texas Health Science Center at Houston, Houston, TX 77030, United States of America. Electronic address:
Administration of substances directly into the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord is one approach that can circumvent the blood-brain barrier to enable drug delivery to the central nervous system (CNS). However, molecules that have been administered by intrathecal injection, which includes intraventricular, intracisternal, or lumbar locations, encounter new barriers within the subarachnoid space. These barriers include relatively high rates of turnover as CSF clears and potentially inadequate delivery to tissue or cellular targets.
View Article and Find Full Text PDFThe Severity of Infection Determines the Localization of Damage and Extent of Sensorineural Hearing Loss in Experimental Pneumococcal Meningitis.
J Neurosci
July 2016
Neuroinfection Laboratory, Institute for Infectious Diseases, University of Bern, 3001 Bern, Switzerland, Cluster for Regenerative Neuroscience, Department of Clinical Research, University of Bern, 3008 Bern, Switzerland
Unlabelled: Hearing loss is an important sequela of pneumococcal meningitis (PM), occurring in up to 30% of survivors. The role of the severity of infection on hearing function and pathomorphological consequences in the cochlea secondary to PM have not been investigated to date. Using a well-established model of PM, we systematically investigated the functional hearing outcome and the long-term fate of neurosensory cells in the cochlea, i.
View Article and Find Full Text PDFImpairment of nuclear pores in bovine herpesvirus 1-infected MDBK cells.
J Virol
January 2005
Electron Microscopy Institute of Veterinary Anatomy, Winterthurerstrasse 266a, CH-8057 Zürich, Switzerland.
Herpesvirus capsids originating in the nucleus overcome the nucleocytoplasmic barrier by budding at the inner nuclear membrane. The fate of the resulting virions is still under debate. The fact that capsids approach Golgi membranes from the cytoplasmic side led to the theory of fusion between the viral envelope and the outer nuclear membrane, resulting in the release of capsids into the cytoplasm.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!