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Loss or inhibition of lysosomal acid lipase leads to cholesteryl ester accumulation without affecting muscle formation or mitochondrial function.
BBA Adv
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Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Skeletal muscle (SM) is essential for movement, stability, and overall body function, and it readily adapts to changes in energy demand. Myogenesis is energy-intensive and involves complex molecular and cellular events. We recently demonstrated that the absence of lysosomal acid lipase (LAL) significantly impacts the SM phenotype, primarily by disrupting energy homeostasis and reducing ATP production.
View Article and Find Full Text PDFUnveiling the Origin of Copper Accumulation in Plasma with Aging.
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January 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Aging is intricately linked to various diseases including cancers, neurodegenerative disorders, and metabolic irregularities. Copper (Cu) overexposure has been found to be linked to many diseases during aging, particularly neurodegenerative diseases. Meanwhile, as an essential element, Cu has been implicated in key processes associated with aging, raising questions about its role in age-related health issues.
View Article and Find Full Text PDFSelenium ameliorates cognitive impairment through activating BDNF/TrkB pathway.
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Department of Epidemiology and Health Statistics, School of Public Health, Ningxia Medical University, Yinchuan 750004, China; Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750004, China. Electronic address:
Background: Alzheimer's disease (AD) is a neurodegenerative disorder that primarily affects older adults. Selenium, an essential micronutrient for humans, plays a crucial role in the body's normal physiological and metabolic processes. A long-term deficiency in selenium intake can lead to various diseases and even contribute to the ageing process.
View Article and Find Full Text PDFShallow groundwater near a deep-well CO storage site-15 years of stable water quality for agricultural use.
Environ Sci Pollut Res Int
January 2025
School of Engineering, Deakin University, Waurn Ponds, Geelong, VIC, 3216, Australia.
Injecting CO into deep geological formations can be an effective carbon removal and storage technology to mitigate global climate change. Interaction of injected CO with rock formations changes pH and hydrochemistry within the deep injection zone (> 800 m depth). However, cap rocks and multiple tight aquitards typically act as barriers to protect the shallow aquifer from changes in the injection zone.
View Article and Find Full Text PDFAdvances in Organic Fluorescent and Colorimetric Probes for The Detection of Cu and Their Applications in Cancer Cell Imaging (2020-2024).
Crit Rev Anal Chem
January 2025
Department of Oral & Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Saudi Arabia.
Organic fluorescence and colorimetric probes have emerged as vital tools for detecting metal ions, due to their high sensitivity, selectivity, and rapid response times. Copper, an essential trace element, plays a critical role in biological systems, yet its imbalance can lead to severe disorders such as neurodegenerative diseases, cancer, and Wilson's disease. Over the past few years, advancements in probe design have unlocked innovative avenues for not only detecting Cu in environmental and biological samples but also for visualizing its distribution through fluorescence imaging.
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