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Enhancing cardiovascular monitoring: a non-linear model for characterizing RR interval fluctuations in exercise and recovery.
Sci Rep
March 2025
Centro Asistencial Docente e Investigación (CADI-UMAG), Universidad de Magallanes, Punta Arenas, Chile.
This work aimed to develop and validate a novel non-linear model to characterize RR interval (RRi) time-dependent fluctuations throughout a rest-exercise-recovery protocol, offering a more precise and physiologically relevant representation of cardiac autonomic responses than traditional HRV metrics or linear approaches. Using data from a cohort of 272 elderly participants, the model employs logistic functions to capture the non-stationary and transient nature of RRi time-dependent fluctuations, with parameter estimation achieved via Hamiltonian Monte Carlo. Sobol sensitivity analysis identified baseline RRi (α) and recovery proportion (c) as the primary drivers of variability, underscoring their critical roles in autonomic regulation and resilience.
View Article and Find Full Text PDFTiny shifts, major ripples: Unravelling micro-mechanisms in the building of mother-infant attachment and psychophysiological regulation.
Infant Behav Dev
March 2025
Brain, Body and Cognition Research Group, Department of Psychology, Faculty of Psychology and Educational Sciences, Vrije Universiteit Brussel, Belgium; Clinical and Lifespan Psychology, Department of Psychology and Educational Sciences, Vrije Universiteit Brussel, Belgium; Vital Signs and PERformance monitoring (VIPER), LIFE Department, Royal Military Academy, Brussels, Belgium; School of Natural Sciences & Psychology, Faculty of Science, Liverpool John Moores University, United Kingdom.
Parental nurturing touch plays a crucial role in early infant development by activating C-Tactile afferents, which trigger neurobiological pathways essential for parent-infant bonding and the building of attachment. This process is said to regulate the infant's parasympathetic nervous system, fostering emotional and physiological connection with the caregiver. Research has consistently shown that CT-mediated touch enhances infant parasympathetic tone, yet no clear patterns of mutual co-regulation between parent and infant have been reported.
View Article and Find Full Text PDFAtrial fibrillation burden in clinical practice, research, and technology development: a clinical consensus statement of the European Society of Cardiology Council on Stroke and the European Heart Rhythm Association.
Europace
March 2025
Clinical Cardiac Academic Group, Genetic and Cardiovascular Sciences Institute, City-St George's University of London, London, UK.
Atrial fibrillation (AF) is one of the most common cardiac diseases and a complicating comorbidity for multiple associated diseases. Many clinical decisions regarding AF are currently based on the binary recognition of AF being present or absent with the categorical appraisal of AF as continued or intermittent. Assessment of AF in clinical trials is largely limited to the time to (first) detection of an AF episode.
View Article and Find Full Text PDFMonitoring sleep of premature infants is a vital aspect of clinical care, as it can reveal potential future pathologies and health issues. This study presents a novel approach to automatically estimate and track Quiet Sleep (QS) in 33 newborns using ECG, respiration, and video motion features. Using an annotated dataset from 15 neonates (10 preterm, 5 full-term) encompassing 127.
View Article and Find Full Text PDFIntroduction of oral methadone to high-risk patients with prolonged QT interval: A retrospective study.
J Opioid Manag
March 2025
Department of Clinical Pharmacy Research and Education, Osaka University Graduate School of Pharmaceutical Sciences, Suita, Osaka, Japan.
Objective: Methadone may cause detrimental side effects such as corrected QT (QTc) prolongation. However, methadone may be desirable in patients with advanced cancer and those with heart disease who have intractable pain. Therefore, we aimed to evaluate the safety and efficacy of initiating methadone for cancer pain in patients at high risk of methadone-induced QTc prolongation.
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