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The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients.
Front Mol Biosci
January 2025
Research Department, Children's Cancer Hospital Egypt, Cairo, Egypt.
Introduction: COVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, and acidosis, yet the key players driving this association remain unclear. It is generally assumed that organ damage causes toxic acidosis, but since neutrophil numbers in severe COVID-19 can exceed 80% of the total circulating leukocytes, we asked if metabolic acidosis mediated by the glycolytic neutrophils is associated with lung damage and impaired oxygen delivery in critically ill patients.
Methods: Based on prospective mortality outcome, critically ill COVID-19 patients were divided into ICU- survivors and ICU-non-survivors.
Cerebral capillary oxygen diffusion: exploring the concept of intracapillary hemoglobin conformational changes.
Intensive Care Med Exp
November 2024
The Ohio State University, Wexner Medical Center N411 Doan Hall, 410 West 10Th Avenue, Columbus, OH, 43210, USA.
The mechanisms of oxygen diffusion in brain capillaries have not been fully clarified to date. According to the laws of physics, the well-documented phenomenon of hyperoxemia-induced excessive increases in brain tissue oxygen pressure (PbtO2) contradicts traditional models of cerebral capillary oxygen diffusion. Circulating models predict a significant drop in oxygen pressure (PO2), and some of them foresee the presence of hypoxic or anoxic corners near the capillary end, regardless of high PbtO2 levels.
View Article and Find Full Text PDFEvolution of the oxyhemoglobin dissociation curve in COVID-19 related ARDS patients.
Front Physiol
November 2024
Intensive Care. CHU-Charleroi Chimay, Université Libre de Bruxelles, Charleroi, Belgium.
Introduction: Severe hypoxemia is the leading cause of admission in intensive care (ICU) in patients with COVID-19 related acute respiratory distress syndrome (ARDS). In these patients, several studies reported a left shift of the oxyhemoglobin dissociation curve associated with a lower mortality. However, these results are conflicting, as these studies include few patients and often no control groups.
View Article and Find Full Text PDFEffects of drugs on the oxygen dissociation curve-a scoping review.
Eur J Clin Pharmacol
February 2025
Department of Anaesthesiology and Intensive Care Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Purpose: The shape and position of the hemoglobin-oxygen dissociation curve (ODC) is of critical importance in medicine, as it determines the uptake of O in the lungs and the delivery of O to the tissues. Numerous reports have identified affinity-modulating effects of drugs in humans. Such effects may be relevant to conditions such as pulmonary diffusion disorders, peripheral vascular disease, or coronary artery disease.
View Article and Find Full Text PDFConformational Dynamics of Hemoglobin in Solution and the Gas Phase Elucidated by Mass Spectrometry.
Anal Chem
December 2024
Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich CH-8093, Switzerland.
Solution and gas-phase measurements can provide valuable insights into biomolecular conformational dynamics. By comparing the data from such experiments, it is possible to elucidate the nature of the interactions governing a biomolecule's stability. Here, we measured human, bovine, and porcine hemoglobin stability in solution and the gas phase using collision-induced dissociation, collision-induced unfolding, surface-induced dissociation, and temperature-controlled nanoelectrospray mass spectrometry.
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