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Objective: The objective of this study was to assess the maturation of matrix-associated autologous chondrocyte transplantation (MACT) grafts up to 2 years after the surgery using gray-level co-occurrence matrix (GLCM) texture analysis of quantitative T maps, compare the results with the microfracturing technique (MFX) control group, and relate these results to the morphological MOCART 2.0 score.

Design: A subcohort of 37 patients from prospective, multi-center study underwent examination on a 3T MR scanner, including a T mapping sequence at 3, 12, and 24 months after surgery.

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Spherical harmonics texture extraction for versatile analysis of biological objects.

PLoS Comput Biol

January 2025

European Molecular Biology Laboratory, Cell Biology and Biophysics Unit, Heidelberg, Germany.

The characterization of phenotypes in cells or organisms from microscopy data largely depends on differences in the spatial distribution of image intensity. Multiple methods exist for quantifying the intensity distribution - or image texture - across objects in natural images. However, many of these texture extraction methods do not directly adapt to 3D microscopy data.

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Heart development involves the complex structural remodelling of a linear heart tube into an asymmetrically looped and ballooned organ. Previous studies have associated regional expansion of extracellular matrix (ECM) space with tissue morphogenesis during development. We have developed morphoHeart, a 3D tissue segmentation and morphometry software with a user-friendly graphical interface (GUI) that delivers the first integrated 3D visualisation and multiparametric analysis of both heart and ECM morphology in live embryos.

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Displacement MMG-based estimation of dynamic muscle viscoelasticity in the quadriceps during passive pedaling.

Sci Rep

January 2025

Graduate School of Interdisciplinary Science and Engineering of Health Systems, Okayama University, Okayama, 700-0082, Japan.

We explore the correlation between muscle viscoelasticity and displacement mechanomyography (DMMG) during passive joint movement. Current methods for assessing muscle viscoelasticity (which is essential for rehabilitation and sports conditioning) are limited in terms of simplicity, objectivity, and portability. We introduce a novel methodology employing DMMG during passive pedaling to evaluate these properties.

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