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Epigallocatechin gallate and vancomycin loaded poly(vinyl)-pyrrolidone-gelatine nanofibers, conceivable curative approach for wound healing.
Colloids Surf B Biointerfaces
January 2025
Department of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi 214000, China. Electronic address:
During surgical procedures, skin and soft tissue wounds are often infected by resistant strains of gram-positive bacteria and gram-negative bacteria, resulting in serious obstacles to the healing of these wounds. Commercially available dressings for such wounds are still insufficient to combat resistant infections. Here, we designed vancomycin and epigallocatechin gallate (EGCG) loaded poly(vinyl)-pyrrolidone-gelatine nanofiber's membrane dressing for potential synergistic efficiency against infected post-surgical wounds.
View Article and Find Full Text PDFContrast-enhanced US of High-Risk Indeterminate Focal Liver Observations Categorized as LR-4 or LR-M at CT/MRI.
Radiology
January 2025
From the Department of Radiology, Thomas Jefferson University Hospital, 132 S 10th St, 763G Main Bldg, Philadelphia, PA 19107 (A.L., C.K.Y.E., T.S.X., S.K.R., C.E.W., K.B., J.R.E., F.F.); Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (F.P.); Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy (F.P.); University of California San Diego, San Diego, Calif (Y.K.); University of Calgary, Calgary, Canada (A.M.K., S.R.W.); Einstein Medical Center, Philadelphia, Pa (S.K.R.); Vanderbilt University, Nashville, Tenn (V.P.); Stanford University, Stanford, Calif (A.K.); UT Southwestern Medical Center, Dallas, Tex (D.T.F.); Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland (A.B., I.P.R.); Department of Imaging Sciences, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom (P.S.S.); and Department of Radiology, King's College Hospital, London, United Kingdom (P.S.S.).
Background Indeterminate focal liver observations in patients at risk for hepatocellular carcinoma (HCC) may require invasive biopsy or follow-up, which could lead to delays in definitive categorization and to postponement of treatment. Purpose To examine clinical effect of contrast-enhanced US (CEUS) in participants with high-risk indeterminate liver observations categorized as Liver Imaging Reporting and Data System (LI-RADS) category LR-4 (probably HCC) or LI-RADS category LR-M (probably or definitely malignant but not HCC specific) at CT or MRI. Materials and Methods This was a secondary analysis of a prospective international multicenter validation study for CEUS LI-RADS (January 2018 to August 2021).
View Article and Find Full Text PDFEvaluation of the Therapeutic Potential of the Methanolic Extract and Fractions of Datura stramonium in Paracetamol-intoxicated Rabbits.
Curr Pharm Des
January 2025
Department of Horticulture and Life Science, Yeungnam University, Republic of Korea.
Introduction: Datura stramonium (DS) possesses strong medicinal and therapeutic potential but has been rarely evaluated in this context.
Methods: The present study was intended to evaluate the antioxidant, hepatoprotective, and nephroprotective potential of the crude methanolic leaf extract and ethyl acetate, chloroform, n-hexane, and aqueous fractions of DS in paracetamol-intoxicated rabbits. Paracetamol (2 g/Kg BW) was applied to induce liver and kidney injury in rabbits while the methanolic extract and fractions of DS were applied in the dose range of 150 mg/Kg to 300 mg/Kg body weight for 21 days.
Occipital bone modeling patterns during the first years of life: A preliminary histological and quantitative approach.
J Anat
January 2025
Laboratorio de Evolución Humana, Universidad de Burgos, Burgos, Spain.
Studies of modeling processes have provided important insights in human evolutionary discipline. Most of these studies are based on facial bones and in much lesser extent on other bones such as those from the cranial vault. Thus, this study fills a gap in research by examining occipital bone modeling in subadults, adding individuals under 2 years old and expanding the sample size available to date.
View Article and Find Full Text PDFQuercetin Supplementation Reduces Oxidative Stress in the Testes of Wistar Rats Fed a High-Fat Diet.
Am J Reprod Immunol
January 2025
Laboratory of Molecular Genetics and Experimentation in Animal Reproduction, University of Western São Paulo (Unoeste), Presidente Prudente, São Paulo, Brazil.
Problem: A high-fat diet (HFD) predisposes animals to glucose intolerance, dyslipidemia and testicular oxidative stress, and impairs sperm production in rats. Quercetin is a flavonoid with antioxidant, anti-inflammatory, and lipolytic actions and is a potential supplement to combat the oxidative stress caused by HFD and its harmful effects on reproduction. This study evaluated the effects of quercetin supplementation at doses of 10 and 20 mg/day on reproductive parameters and testicular oxidative stress in Wistar rats fed a diet rich in pork fat and fructose.
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