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Molecular detection of Wolbachia sp. and Cytoplasmic incompatibility factors (CifA/B) in wild caught mosquitoes in Côte d'Ivoire.
Mol Biol Rep
January 2025
Equipe Biologie Moléculaire et Biotechnologies, Laboratoire de Recherche, Centre MURAZ, Institut National de Santé Publique, Bobo-Dioulasso, Burkina Faso.
Background: Wolbachia is an endosymbiont bacterium known to stimulate host immunity against arboviruses and protozoa. Côte d'Ivoire is in a malaria-endemic region, and has experienced several dengue epidemics in recent decades as well. In order to help reduce the transmission of pathogens by mosquito vectors, we studied the prevalence of Wolbachia and the distribution of Cytoplasmic incompatibility factors (Cif) genes in different mosquito species caught in the wild in Cote d'Ivoire.
View Article and Find Full Text PDFStructural Basis and Mechanism of a Unique Haemophore in the Haem-Iron Acquisition by Riemerella anatipestifer.
Adv Sci (Weinh)
January 2025
Engineering Research Center of Southwest Animal Disease Prevention and Control Technology, Ministry of Education of the People's Republic of China, Chengdu, 611130, China.
Several bacterial pathogens employ haemophores to scavenge haem from host haemoprotein to obtain an iron source. However, no homologues of well-characterized haemophores are found in Riemerella anatipestifer, a bacterium belonging to the order Flavobacteriales that encodes haem uptake systems. Herein, a unique haemophore RhuH is characterized in this bacterium.
View Article and Find Full Text PDFSN-38-indoximod conjugate: carrier free nano-prodrug for cancer therapy.
Ther Deliv
January 2025
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan.
Background: The integration of immunotherapy alongside chemotherapy represents a crucial approach in the treatment of cancer. Herein we report the SN-38-indoximod conjugate nano-prodrug to address the difficulties encountered by individuals. In this prodrug, SN-38 is connected to indoximod through a specific disulfide linker, which enables the release of the components in response to the tumor microenvironment characterized by elevated levels of glutathione, thereby facilitating programmed chemoimmunotherapy.
View Article and Find Full Text PDFDevelopment and Characterization of Oral Efavirenz-Loaded Nanostructured Lipid Carriers and Their Optimization with Box-Behnken Design Approach for the Neurological Disorder.
Assay Drug Dev Technol
January 2025
Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, India.
In vitro In vitro
View Article and Find Full Text PDFChemical Constituents and Particle Size Distribution of Mainstream Emission from Electronic Waterpipe.
Nicotine Tob Res
January 2025
Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Introduction: An electronic waterpipe (electronic hookah) uses an electronic heating element to promote the vaporization and aerosolization of an e-liquid in a waterpipe. There is little or no published information characterizing the toxicant levels or particle size distributions of electronic waterpipe mainstream emission.
Methods: Controlled laboratory experiments were performed to evaluate electronic waterpipe mainstream emission for 40 test conditions: 10 e-liquid products × 2 power settings × 2 puffing topographies.
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