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A vagal reflex evoked by airway closure.
Nature
March 2024
Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Airway integrity must be continuously maintained throughout life. Sensory neurons guard against airway obstruction and, on a moment-by-moment basis, enact vital reflexes to maintain respiratory function. Decreased lung capacity is common and life-threatening across many respiratory diseases, and lung collapse can be acutely evoked by chest wall trauma, pneumothorax or airway compression.
View Article and Find Full Text PDFInhibitory effect of sulfur dioxide inhalation on Hering-Breuer inflation reflex in mice: role of voltage-gated potassium channels.
J Appl Physiol (1985)
May 2023
Department of Physiology, University of Kentucky Medical Center, Lexington, Kentucky, United States.
Slowly adapting receptors (SARs), vagal mechanosensitive receptors located in the lung, play an important role in regulating the breathing pattern and Hering-Breuer inflation reflex (HBIR). Inhalation of high concentration of sulfur dioxide (SO), a common environmental and occupational air pollutant, has been shown to selectively block the SAR activity in rabbits, but the mechanism underlying this inhibitory effect remained a mystery. We carried out this study to determine if inhalation of SO can inhibit the HBIR and change the eupneic breathing pattern, and to investigate further a possible involvement of voltage-gated K channels in the inhibitory effect of SO on these vagal reflex-mediated responses.
View Article and Find Full Text PDFA historical perspective of pulmonary rapidly adapting receptors.
Respir Physiol Neurobiol
May 2021
Department of Medicine University of Louisville, Louisville, KY, 40292, USA; Robley Rex VA Medical Center, Louisville, KY, 40206, USA. Electronic address:
Bronchopulmonary mechanosensors play an important role in the regulation of breathing and airway defense. Regarding the mechanosensory unit, investigators have conventionally adhered to 2 doctrines: one-sensor theory (one afferent fiber connects to a single sensor) and line-labeled theory. Accordingly, lung inflation activates 2 types of mechanosensors: slowly adapting receptors (SARs) and rapidly adapting receptors (RARs) that also respond to lung deflation to produce Hering-Breuer deflation reflex.
View Article and Find Full Text PDFReflexes that impact spontaneous breathing of preterm infants at birth: a narrative review.
Arch Dis Child Fetal Neonatal Ed
November 2020
Neonatology, Leiden University Medical Center, Leiden, The Netherlands.
Some neural circuits within infants are not fully developed at birth, especially in preterm infants. Therefore, it is unclear whether reflexes that affect breathing may or may not be activated during the neonatal stabilisation at birth. Both sensory reflexes (eg, tactile stimulation) and non-invasive ventilation (NIV) can promote spontaneous breathing at birth, but the application of NIV can also compromise breathing by inducing facial reflexes that inhibit spontaneous breathing.
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