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Metabolite Predictors of Breast and Colorectal Cancer Risk in the Women's Health Initiative.
Metabolites
August 2024
Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Metabolomics has been used extensively to capture the exposome. We investigated whether prospectively measured metabolites provided predictive power beyond well-established risk factors among 758 women with adjudicated cancers [ = 577 breast (BC) and = 181 colorectal (CRC)] and = 758 controls with available specimens (collected mean 7.2 years prior to diagnosis) in the Women's Health Initiative Bone Mineral Density subcohort.
View Article and Find Full Text PDFEffect on serum metabolomics of rats with premature ovarian insufficiency by Zhibian (BL54) through Shuidao (ST28) acupuncture.
J Tradit Chin Med
August 2024
Department of Cervical and Lumbar Vertebral Diseases, Jinzhong Hospital Affiliated to Shanxi University of Traditional Chinese Medicine, Jinzhong 030600, China.
Article Synopsis
- The study investigates the effects of the "Zhibian (BL54) through Shuidao (ST28)" acupuncture technique on serum metabolite levels in rats with cyclophosphamide-induced premature ovarian insufficiency (POI).
- By comparing hormone levels and ovarian tissue changes in acupuncture-treated and untreated POI rats, the researchers aimed to evaluate the effectiveness of this acupuncture method.
- Results indicated that acupuncture significantly improved ovarian function by altering specific serum metabolites linked to reproductive hormone regulation and protective effects against cell damage, suggesting its potential for treating POI in clinical settings.
Bacteroidales reduces growth rate through serum metabolites and cytokines in Chinese Ningdu yellow chickens.
Poult Sci
August 2024
Jiangxi Provincial Key Laboratory of Poultry Genetic Improvement, Nanchang Normal University, Nanchang, Jiangxi 330032, China.
Increasing evidence has indicated that the gut microbiome plays an important role in chicken growth traits. However, the cecal microbial taxa associated with the growth rates of the Chinese Ningdu yellow chickens are unknown. In this study, shotgun metagenomic sequencing was used to identify cecal bacterial species associated with the growth rate of the Chinese Ningdu yellow chickens.
View Article and Find Full Text PDFRapid and sensitive detection of SARS-CoV-2 virus in human saliva samples using glycan based nanozyme: a clinical study.
Mikrochim Acta
December 2023
Department of Chemical Engineering and Energy, Quchan University of Technology, Quchan, 94771-67335, Iran.
A highly sensitive colorimetric method (glycan-based nano(e)zyme) was developed for sensitive and rapid detection of the SARS-CoV-2 virus based on N-acetyl neuraminic acid (sialic acid)-functionalized gold nanoparticles (SA-Au NZs). A number of techniques were used to characterize the prepared nanomaterials including XRD, FT-IR, UV-vis, DLS, and TEM. DLS analysis indicates an average hydrodynamic size of 34 nm, whereas TEM analysis indicates an average particle size of 15.
View Article and Find Full Text PDFFunctional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors.
PLoS Pathog
September 2023
Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America.
The complement system is the first line of innate immune defense against microbial infections. To survive in humans and cause infections, bacterial pathogens have developed sophisticated mechanisms to subvert the complement-mediated bactericidal activity. There are reports that sialidases, also known as neuraminidases, are implicated in bacterial complement resistance; however, its underlying molecular mechanism remains elusive.
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