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Cat scratch disease (CSD) is a zoonotic disease transmitted to humans, usually via scratches or bites. is the primary causative agent. It causes a mild, self-limiting disease.

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Background: Tyrosine kinase inhibitors (TKIs) and immunotherapy have been proposed for advanced metastatic anaplastic thyroid cancer (ATC). We report a case of V600E-mutated ATC in which lenvatinib (L) plus pembrolizumab (P) enabled neoadjuvant treatment.

Case Presentation: A male patient aged 65 years presented with a rapidly enlarging left latero-cervical mass.

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Spider Bite Presenting as Fever, Macrophage Activation Syndrome and a Skin Ulcer.

Eur J Case Rep Intern Med

May 2024

Internal Medicine and Alcohol Related Disease Unit, Department of Medical and Surgical Sciences, Columbus-Gemelli Hospital, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Article Synopsis
  • - Fever of unknown origin (FUO) can often be caused by infections, such as loxoscelism from fiddleback spider bites, which can lead to severe systemic symptoms like fever and necrotic skin lesions.
  • - A case study of a 71-year-old man highlighted the challenges in diagnosing FUO as he presented with fever, joint pain, and a necrotic arm lesion but initial tests were inconclusive; he eventually developed macrophage activation syndrome (MAS) and was diagnosed with both loxoscelism and primary cutaneous anaplastic large cell lymphoma.
  • - It's crucial to biopsy skin lesions and lymph nodes of unknown origin, as repeated evaluations may be necessary to avoid misdiagnosis, especially
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Ingestion of corrosive substances is most common in children, while in adults causes more severe damages. Massive ingestion of corrosive substances results in severe damage to the gastrointestinal tract and oropharynx if not treated properly. Corrosive substances with pH<2 or >12 can result in severe esophageal damage with either colliquative (alkaline) or coagulative (acidic) necrosis and, at the same time various gastrointestinal injuries could lead to late post-corrosive complications.

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Background: H Syndrome is a rare genetic condition caused by biallelic pathogenic variants in the SLC29A3 gene. It is characterized by a wide range of clinical manifestations, many of which are related to the immune-rheumatological field. These include scleroderma-like skin changes, deforming arthritis, and enlarged lymph nodes.

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