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Seroprevalence of IgG antibodies against tetanus toxoid among different age groups in Poland.
Ann Agric Environ Med
September 2024
National Institute of Public Health NIH - National Research Institute, Warsaw, Poland.
Article Synopsis
- The study aimed to assess the prevalence of tetanus antibodies in the population to gauge vaccine-induced immunity and identify groups needing booster shots.* -
- A total of 2,842 serum samples from individuals aged 1 month to 97 years were tested, revealing that 5.2% had low antibody levels and over half required immediate booster vaccinations.* -
- Results indicated that young adults showed the highest antibody levels and avidity, while older adults (70+) had significantly lower immunity, suggesting they are the main target for booster doses.*
Phase 1 trial of an investigational Tdap booster vaccine with CpG 1018 adjuvant compared with Boostrix in healthy adults and adolescents.
Vaccine
October 2024
Dynavax Technologies Corporation, Emeryville, CA, USA. Electronic address:
This phase 1 trial assessed the safety and immunogenicity of an investigational tetanus/diphtheria/acellular pertussis vaccine combined with CpG 1018 adjuvant 1500 μg (Tdap-1018 1500 μg) or 3000 μg (Tdap-1018 3000 μg) in adults and adolescents. In this randomized, active-controlled, multicenter, dose-escalation trial, healthy participants aged 10 to 22 years received 1 dose of Tdap-1018 1500 μg, Tdap-1018 3000 μg, or Boostrix. Geometric mean concentrations (GMCs) and booster response rates (BRRs) for antibodies against pertussis (pertussis toxin, filamentous hemagglutinin, pertactin), tetanus, and diphtheria antigens, and neutralizing antibodies against pertussis toxin were assessed 4 weeks after vaccination.
View Article and Find Full Text PDFDilution of humoral immunity: Results from a natural history study of healthy total knee arthroplasty patients.
J Orthop Res
December 2024
Department of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, Virginia, USA.
The incidence of prosthetic joint infection (PJI) following elective primary total knee arthroplasty (TKA) is very low but serious risk remains. To identify unknown risk factors, we completed a natural history study of IgG specific for Staphylococcus aureus antigens previously phenotyped as protective (anti-Atl) and pathogenic (anti-Isd). Twenty-five male and 25 female optimized patients 50-85 years of age and BMI 24-39 undergoing primary TKA were prospectively enrolled.
View Article and Find Full Text PDFCharacterization of neutralizing chimeric heavy-chain antibodies against tetanus toxin.
Hum Vaccin Immunother
December 2024
Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Article Synopsis
- Tetanus toxin (TeNT) is highly toxic, but researchers developed 14 anti-tetanus nanobodies from a camel's immune response to the toxin's receptor-binding domain.
- Three specific nanobodies, T83-7, T83-8, and T83-13, showed strong binding and effectively protected mice from lethal doses of TeNT, with T83-13 providing full protection even when administered two weeks prior to toxin exposure.
- These findings suggest that these nanobodies can be used for both prevention and treatment of tetanus, paving the way for potential therapeutic drugs against TeNT toxicity.
Safety and immunogenicity of a single dose of Tdap compared to Td in pregnant women in Mali and 3 its effect on infant immune responses: a single-centre, randomised, double-blind, active-controlled phase 2 study.
EClinicalMedicine
May 2024
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Background: While maternal pertussis vaccination is a strategy to reduce infant morbidity, safety and immunogenicity data are limited in sub-Saharan Africa. We aimed to evaluate the safety of a single dose of tetanus, diphtheria and acellular pertussis vaccine (Tdap) vaccine compared to tetanus and diphtheria vaccine (Td) vaccine in pregnant women in Bamako, Mali and to assess the pertussis toxin (PT) antibody response at birth.
Methods: In this phase 2, single-centre, randomised, double-blind, active-controlled study, from 23 January 2019 to 10 July 2019, healthy 18-39 year old women in the second trimester of a singleton pregnancy were randomised 2:1 to receive Tdap or Td.
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