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A case of cutaneous melanoma metastatic to the ciliary body and choroid with complete regression via systemic dual checkpoint inhibitor therapy.
BMC Ophthalmol
January 2025
Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA.
Background: Cutaneous melanoma is the leading cause of death from cutaneous malignancy and tends to metastasize lymphatically and hematogenously to the lung, liver, brain, and bone; it is a rare source of metastatic disease to the eye. Herein we provide a case report of cutaneous melanoma metastatic to the ciliary body and choroid involving clinical examination, slit lamp photography, and B-scan ultrasonography.
Result: A 55-year-old female with known metastatic cutaneous melanoma presented with pain, a large ciliochoroidal mass, visual decline, and diffuse intraocular inflammation.
The importance of clinical experience in AI-assisted corneal diagnosis: verification using intentional AI misleading.
Sci Rep
January 2025
Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, Japan.
We developed an AI system capable of automatically classifying anterior eye images as either normal or indicative of corneal diseases. This study aims to investigate the influence of AI's misleading guidance on ophthalmologists' responses. This cross-sectional study included 30 cases each of infectious and immunological keratitis.
View Article and Find Full Text PDFThe influence of architectural heritage and tourists' positive emotions on behavioral intentions using eye-tracking study.
Sci Rep
January 2025
Faculty of Innovation and Design, City University of Macau, Macau, China.
The city's rapid development would lead to irreversible changes in architectural heritage. As one of the ways to promote sustainable development, world heritage tourism has opened up a new perspective for the protection, inheritance and development of architectural heritage. Taking the study of architectural heritage in the Historic Centre of Macau as an example, employing eye-tracking experiment and semantic differential method (SD method) to explore the relationship between tourists' perceptions of visual elements of architectural heritage, positive emotions, and behavioral intentions.
View Article and Find Full Text PDFThe influence of repeated frowning and smiling on corrugator muscle activity and wrinkles between eyebrows.
Sci Rep
January 2025
MIRAI Technology Institute, Shiseido Co., Ltd., 1-2-11 Takashima, Nishi-ku, Yokohama, 220-0011, Kanagawa, Japan.
Like the lines themselves, concerns about facial wrinkles, particularly glabellar lines - the prominent furrows between the eyebrows - intensify with age. These lines can inadvertently convey negative emotions due to their association with negative facial expressions. We investigated the effects of repeated frowning on the development of temporary glabellar lines through the activation of the corrugator muscle.
View Article and Find Full Text PDFTreatment of pseudophakic aqueous misdirection syndrome.
Sci Rep
January 2025
Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.
To describe the management and clinical course of 12 cases of pseudophakic aqueous misdirection syndrome (AMS). Twelve eyes of 12 Patients diagnosed with pseudophakic AMS between 2021 and 2022 were included. Best-corrected visual acuity, refraction, intraocular pressure (IOP), anti-glaucomatous medication, spectral domain ocular coherence tomography (SD-OCT) and postoperative complications were evaluated.
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