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Na-K-ATPase/GLT-1 interaction participates in EGCG protection against cerebral ischemia-reperfusion injury in rats.
Phytomedicine
January 2025
Hebei Key Laboratory of Critical Disease Mechanism and Intervention, Department of Pathophysiology, Neuroscience Research Center, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017, China. Electronic address:
Background: In China, stroke is the primary cause of adult death and disability. Because of the increased rate of blood vessel reperfusion, it is important to prevent cerebral ischemia-reperfusion injury, in which glutamate (Glu) excitotoxicity plays a critical role. The most important Glu transporter, GLT-1, is essential for the regulation of Glu, which is dependent on Na-K-ATPase (NKA)-induced ion concentration gradient differences.
View Article and Find Full Text PDFMarine Fungi Bioactives with Anti-Inflammatory, Antithrombotic and Antioxidant Health-Promoting Properties Against Inflammation-Related Chronic Diseases.
Mar Drugs
November 2024
Hephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, Kavala University Campus, St. Lucas, 65404 Kavala, Greece.
Fungi play a fundamental role in the marine environment, being promising producers of bioactive molecules in the pharmacological and industrial fields, which have demonstrated potential health benefits against cardiovascular and other chronic diseases. This review pertains to the analysis of the lipid compositions across various species of marine fungi and their constantly discovered substances, as well as their anti-inflammatory, antioxidant, and antithrombotic effects. The health-promoting aspects of these microorganisms will be explored, through the investigation of several mechanisms of action and interference of their bioactives in biochemical pathways.
View Article and Find Full Text PDFAdipokines and their potential impacts on susceptibility to myocardial ischemia/reperfusion injury in diabetes.
Lipids Health Dis
November 2024
Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macao, PR, China.
Article Synopsis
- Coronary artery disease poses a significant public health risk, with myocardial ischemia often requiring immediate treatments like thrombolytic therapy to restore blood flow; however, this can lead to additional damage known as ischemia/reperfusion (I/R) injury.
- Diabetes increases the heart's susceptibility to I/R injury due to issues with metabolism and heightened inflammatory responses, making the roles of adipokines crucial in this context.
- The review explores recent findings on various adipokines, some of which offer protective effects against heart damage in conditions like obesity and diabetes, while others may worsen inflammation and damage, underscoring the need for further research in this area.
Blood hypercoagulability and thrombosis mechanisms in cancer patients -A brief review.
Heliyon
October 2024
Department of Blood Transfusion, Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Zhenjiang, 212000, PR China.
Article Synopsis
- * Current research focuses on various mechanisms contributing to this hypercoagulability, including the release of coagulation-promoting substances by tumor cells and their interaction with the fibrinolytic system and platelets.
- * Understanding these mechanisms is crucial for developing new drugs and treatment strategies to improve patient outcomes and survival rates.
Recent advancement of novel marine fungi derived secondary metabolite fibrinolytic compound FGFC in biomedical applications: a review.
Front Cell Infect Microbiol
October 2024
College of Natural Sciences, Arba Minch University, SNNPR, Arba Minch, Ethiopia.
For several decades, products derived from marine natural sources (PMN) have been widely identified for several therapeutic applications due to their rich sources of bioactive sub-stances, unique chemical diversity, biocompatibility and excellent biological activity. For the past 15 years, our research team explored several PMNs, especially fungi fibrinolytic compounds (FGFCs). FGFC is an isoindolone alkaloid derived from marine fungi, also known as staplabin analogs or triprenyl phenol (SMTP).
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