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Japanese Leaf Burdock Extract Inhibits Adipocyte Differentiation in 3T3-L1 Cells.
Plant Foods Hum Nutr
January 2025
Department of Food Science and Nutrition, School of Food Science and Nutrition, Mukogawa Women's University, 6-46, Ikebiraki-Cho, Nishinomiya, Hyogo, 663-8558, Japan.
Burdock, Arctium lappa Linn. (Asteraceae), is cultivated in East Asian for its edible roots, and its seeds are used in a herbal medicine. Burdock seeds and roots exhibit anti-adipogenic activity.
View Article and Find Full Text PDFRapid microcystin-LR detection using antibody-based electrochemical biosensors with a simplified calibration curve approach.
Sci Rep
December 2024
Department of Civil, Environmental and Construction Engineering, University of Central Florida, Orlando, FL, USA.
Harmful algal blooms (HABs) can release cyanotoxins such as microcystins (MCs), especially, microcystin-leucine-arginine (MC-LR) which is one of the commonest and most toxic, into our water bodies and can lead to several acute or chronic diseases such as liver diseases and respiratory irritation in humans. There is an increasing need for rapid and simple detection of MC-LR in water bodies for early warning of HABs. In this study, we developed an innovative on-site screening electrochemical impedance spectroscopy (EIS) biosensor with a simplified calibration curve that can rapidly detect blooms for early action in similar water bodies.
View Article and Find Full Text PDFExperimental study on the inhibitory effect of Halofuginone on NSCLC.
Eur J Pharmacol
February 2025
School of Pharmacy, Bengbu Medical University, Bengbu, China; Anhui Province Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, China. Electronic address:
In recent decades, significant advancements have been achieved in non-small cell lung cancer (NSCLC) treatment. However, drug resistance, postoperative recurrence, distant metastasis, and other critical issues arise during NSCLC treatment. Natural products play a crucial role in the development of anti-tumor drugs.
View Article and Find Full Text PDFPatient journey in cystinosis: focus on non-adherence and disease management.
Drugs Context
November 2024
Chiesi España S.A.U., Barcelona, Spain.
Background: Few studies have assessed patient-reported experience measures in nephropathic cystinosis. This study uses patient reports focused on the impact of cystinosis, cysteamine treatment-associated problems, and therapeutic adherence and suggests potential actions for improvement.
Methods: In March 2022, six patients with nephropathic cystinosis treated with cysteamine, aged between 12 and 40 years as well as two caregivers, underwent standardized online interviews.
Mechanism of action and impact of thiol homeostasis on efficacy of an enzyme replacement therapy for classical homocystinuria.
Redox Biol
November 2024
Department of Pharmacology, University of Fribourg, Faculty of Science and Medicine, Fribourg, Switzerland. Electronic address:
Article Synopsis
- Homocystinuria (HCU) is caused by a deficiency in the enzyme cystathionine beta-synthase (CBS), leading to high levels of homocysteine in the body; it can be managed through a special diet and vitamin B supplementation, but there is currently no cure.
- Recent research shows that enzyme replacement therapy (ERT) using human CBS can significantly lower homocysteine levels in mice, though it doesn't fully normalize them, prompting further investigation into how ERT works.
- The study found that reducing homocysteine levels enhances CBS function, and using biological reductants like N-acetylcysteine can improve the effectiveness of CBS-based ERT, offering new ways to tackle H
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