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Transposable element exonization generates a reservoir of evolving and functional protein isoforms.
Cell
December 2024
Institut Curie, PSL University, Inserm U932, Immunity and Cancer, 75005 Paris, France. Electronic address:
Alternative splicing enhances protein diversity in different ways, including through exonization of transposable elements (TEs). Recent transcriptomic analyses identified thousands of unannotated spliced transcripts with exonizing TEs, but their contribution to the proteome and biological relevance remains unclear. Here, we use transcriptome assembly, ribosome profiling, and proteomics to describe a population of 1,227 unannotated TE exonizing isoforms generated by mRNA splicing and recurrent in human populations.
View Article and Find Full Text PDFChemoresistance-motility signature of molecular evolution to chemotherapy in non-muscle-invasive bladder cancer and its clinical implications.
Cancer Lett
February 2025
Department of Biomedical Sciences, Dong-A University, Busan, 49315, South Korea; Department of Health Sciences, The Graduated of Dong-A University, Busan, 49315, South Korea. Electronic address:
Article Synopsis
- * The researchers created a 63-gene signature called Chemoresistance-Motility (CrM) to study how NMIBC evolves over time and used it to analyze 1,846 samples, revealing that early resistance stages are linked to increased cell movement and metastasis.
- * The study suggests that patients with high CrM scores have worse outcomes, ineffective responses to BCG and immune therapies, and identifies five alternative drugs to gemcitabine that may be effective, proposing a need for further validation of these findings.
Tumor-associated macrophages in bladder cancer: roles and targeted therapeutic strategies.
Front Immunol
November 2024
Department of Urology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Bladder cancer (BC) is the ninth most common and "expensive" cancer in the world. Despite the availability of various treatment modalities such as chemotherapy, immunotherapy and surgery, the overall survival rate of patients with advanced bladder cancer remains low. As one of the most abundant infiltrating immune cells in bladder cancer, tumor-associated macrophages (TAMs) play an important role in the development of BC and in the standard regimen of intravesical BCG therapy.
View Article and Find Full Text PDFTimeliness of 24 childhood immunisations and evolution of vaccination delay: Analysis of data from 54 low- and middle-income countries.
PLOS Glob Public Health
November 2024
MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.
Vaccination timeliness is often not considered among standard performance indicators of routine vaccination programmes, such as vaccination coverage, yet quantifying vaccination delay could inform policies to promote in-time vaccination and help design vaccination schedules. Here, we analysed vaccination timeliness for 24 routine childhood immunisations for 54 countries. We extracted individual vaccination status and timing from Demographic and Health Surveys data from 54 countries with surveys from 2010 onwards.
View Article and Find Full Text PDFMarine sponge microbe provides insights into evolution and virulence of the tubercle bacillus.
PLoS Pathog
August 2024
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
Reconstructing the evolutionary origins of Mycobacterium tuberculosis, the causative agent of human tuberculosis, has helped identify bacterial factors that have led to the tubercle bacillus becoming such a formidable human pathogen. Here we report the discovery and detailed characterization of an exceedingly slow growing mycobacterium that is closely related to M. tuberculosis for which we have proposed the species name Mycobacterium spongiae sp.
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