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A Rare Sequela of Untreated Streptococcus Pharyngitis: A Case Report.
Laryngoscope
January 2025
Ohio University Heritage College of Osteopathic Medicine, Dublin, Ohio, U.S.A.
Pharyngitis is commonly caused by the gram positive bacteria, streptococcus. Given the potential morbid complications of untreated streptococcal pharyngitis, antibiotics are critical. One of the rarer complications is pulmonary-renal syndrome (PRS), defined as rapidly progressive glomerulonephritis and diffuse alveolar hemorrhage.
View Article and Find Full Text PDFMicroscopic polyangiitis in pediatric systemic lupus erythematosus: a unique presentation of pulmonary-renal syndrome and case report of an overlap syndrome.
CEN Case Rep
December 2024
Department of Nephrology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dongfang Road, Shanghai, China.
Secondary vasculitis is encountered in about one-third of all cases of systemic lupus erythematosus (SLE). Skin is most commonly involved in lupus-related small vasculitis. Although antineutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) is relatively uncommon, it can be the most dangerous manifestation associated with high mortality.
View Article and Find Full Text PDFSocioeconomic Disparities in the Utilization of Endoscopic Transsphenoidal Pituitary Surgery: A Retrospective Analysis of the National Inpatient Sample.
World Neurosurg
January 2025
Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, USA.
Article Synopsis
- - Pituitary neoplasms make up 15% of intracranial tumors, affecting around 20% of people, prompting a study using the National Inpatient Sample (NIS) to explore disparities in endoscopic pituitary surgery outcomes.
- - An analysis from 2010 to 2020 showed a decline in hospitalization rates for this surgery and highlighted that most patients were aged 25 to 64, with many having no other health issues.
- - Disparities were observed in racial and socioeconomic groups, with Black and Hispanic patients facing more complications and higher mortality risks post-surgery compared to White patients, especially those on Medicaid.
Critically Ill Patients with Newly Diagnosed Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Case Series and Literature Review.
J Clin Med
September 2024
Department of Internal Medicine, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
ANCA-associated vasculitides (AAVs) are rare diseases with a prevalence of less than 200 cases per million persons and an incidence of less than 25 cases per million person-years. Their presenting features can vary from prodromal and nonspecific symptoms to dramatic organ-specific symptoms such as respiratory failure due to diffuse alveolar hemorrhage (DAH) and acute kidney injury (AKI). The latter two are hallmark features of pulmonary-renal syndrome, a potentially fatal condition that necessitates early recognition and treatment in intensive care units (ICUs) and rapid induction of immunosuppressive therapy.
View Article and Find Full Text PDFMicroRNAs Regulate the Expression of Genes Related to the Innate Immune and Inflammatory Response in Rabbits Infected with GI.1 and GI.2 Genotypes.
Int J Mol Sci
September 2024
Institute of Biology, University of Szczecin, St. Z. Felczaka 3c, 71-412 Szczecin, Poland.
Article Synopsis
- MicroRNAs (miRs) are small RNA molecules that control gene expression and can lead to diseases if their regulation goes awry.
- The study focuses on the impact of specific miRs (miR-155, miR-146a, miR-223, and miR-125b) on immune responses during rabbit hemorrhagic disease (RHD), which has symptoms similar to acute liver failure in humans.
- Findings indicate that the behavior of these miRs varies by tissue, with miR-155 having mixed inflammatory effects, while miR-146a and miR-223 mostly provide anti-inflammatory responses, suggesting that these molecules play a crucial role in the disease's pathogenesis.
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