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Behavioral Cetology in the 19th Century: Thomas Beale, Henry Cheever, Thomas Southwell and Their Role in Awakening a Cetacean Protection Consciousness.
J Hist Behav Sci
January 2025
Department of Psychology, Oklahoma State University, Stillwater, Oklahoma, USA.
Although naturalists have devoted attention to cetaceans since Antiquity, it was only in the 19th century that cetology underwent a true explosion. Three key cetological works of this period are The Natural History of the Sperm Whale (1839) by Thomas Beale, The Whaleman's Adventures in the Southern Ocean (1850) by Henry Cheever and The Seals and Whales of the British Seas (1881) by Thomas Southwell. Importantly, these three works did not only represent fundamental compendia of scientific knowledge of cetaceans, but also had a crucial role in awakening a cetacean protection consciousness.
View Article and Find Full Text PDFUnlocking hexafluoroisopropanol as a practical anion-binding catalyst for living cationic polymerization.
Angew Chem Int Ed Engl
January 2025
Chang Chun Institute of Applied Chemistry Chinese Academy of Sciences, Key Laboratory of Polymer Ecomaterials, 5625 Renmin Street, Changchun, , 130022, Changchun, CHINA.
Living cationic polymerization (LCP) is a classical technique for precision polymer synthesis; however, due to the high sensitivity of cationic active species towards chain-transfer/termination events, it is notoriously difficult to control polymerization under mild conditions, which inhibits its progress in advanced materials engineering. Here, we unlock a practical anion-binding catalytic strategy to address the historical dilemma in LCP. Our experimental and mechanistic studies demonstrate that commercially accessible hexafluoroisopropanol (HFIP), when used in high loading, can create higher-order HFIP aggregates to tame dormant-active species equilibrium via non-covalent anion-binding principle, in turn inducing distinctive polymerization kinetics behaviors that grant efficient chain propagation while minimizing competitive side reactions.
View Article and Find Full Text PDFNivolumab and hypofractionated radiotherapy in patients with advanced melanoma: A phase 2 trial.
Eur J Cancer
January 2025
Department of Dermatology, Côte d'Azur University, University Hospital Center of Nice, France.
Background: Radiotherapy is thought to enhance anti-tumor immunity, particularly when delivered in a hypofractionated and multisite manner. Therefore, we investigated the effects of combining radiotherapy with nivolumab in patients with advanced melanoma.
Methods: This was a multicenter, non-randomized, phase 2 trial that enrolled patients with treatment-naïve metastatic melanoma.
Rationale and Design of the Prevail Global Trial Program Evaluating the Prevail Drug-Coated Balloon in Patients with In-stent Restenosis and De Novo Small Vessel Disease.
Am Heart J
January 2025
Clinical and Experimental Interventional Cardiology, University of Saarland, Homburg, Germany.
Background And Rationale: In-stent restenosis (ISR) remains the leading cause of treatment failure following percutaneous coronary intervention (PCI) with contemporary drug-eluting stents. Especially in small caliber coronary arteries, restenosis is common following PCI and represents a treatment challenge. Drug-coated balloons (DCB) are an attractive alternative to stents for treatment of both ISR and small vessel disease.
View Article and Find Full Text PDFDevelopment of Primer Panels for Whole-Genome Amplification and Sequencing of Human Seasonal Coronaviruses: hCoV-OC43, hCoV-HKU1, hCoV-229E, and hCoV-NL63.
Viruses
December 2024
Smorodintsev Research Institute of Influenza, 197376 Saint Petersburg, Russia.
Human seasonal coronaviruses (hCoVs) are a group of viruses that affect the upper respiratory tract. While seasonal patterns and the annual variability of predominant hCoV species are well-documented, their genetic and species diversity in St. Petersburg and across Russia remains largely unexplored.
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