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Pathogenic, but Not Nonpathogenic, spp. Evade Inflammasome-Dependent IL-1 Responses To Establish an Intracytosolic Replication Niche.
mBio
February 2021
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
species (spp.) are strict obligate intracellular bacteria, some of which are pathogenic in their mammalian host, including humans. One critical feature of these stealthy group of pathogens is their ability to manipulate hostile cytosolic environments to their benefits.
View Article and Find Full Text PDFAntibiotic Response to Pediatric Scrub Typhus in South India: Is Clinical Failure to Azithromycin to be Worried?
J Trop Pediatr
January 2021
Department of Pediatrics, MGMCRI, Puducherry 607402, India.
Background: Scrub typhus is typically associated with a rapid defervescence and clinical improvement within 48 h of initiation of appropriate antibiotics. But increasing reports of resistance to anti-rickettsial medications in scrub typhus are being reported in the literature.
Methods: This is a retrospective observational study of children up to the age of 14 years admitted between July 2017 and March 2020, to a private medical college hospital in southern part of India.
Prompt defervescence after initiation of treatment for rickettsial infections - time to dispense with the dogma?
Int J Infect Dis
January 2021
Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia; The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia. Electronic address:
Introduction: Clinicians are commonly taught that if patients with suspected rickettsial disease have continuing fever after 48 hours of anti-rickettsial therapy, an alternative diagnosis is likely.
Methods: This retrospective study of patients hospitalised with scrub typhus and Queensland tick typhus (QTT) in tropical Australia, examined the time to defervescence after initiation of the patients' anti-rickettsial therapy. It also identified factors associated with delayed defervescence (time to defervescence >48 hours after antibiotic commencement).
Seroprevalence of Dengue Virus and Rickettsial Infections in Cambodian Children.
Am J Trop Med Hyg
March 2019
Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
Scrub typhus (ST, ), murine typhus (MT, ), and dengue virus (DENV) are important causes of childhood morbidity in Cambodia. This prospective, cross-sectional seroprevalence study determined the proportion of Cambodian children infected by these pathogens and the ages at which initial infection is likely to occur. A total of 993 patient serum samples were tested for MT- and ST-specific IgG, and 837 samples tested for DENV-specific IgG.
View Article and Find Full Text PDFMurine models of scrub typhus associated with host control of Orientia tsutsugamushi infection.
PLoS Negl Trop Dis
March 2017
Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Center for Tropical Diseases, Sealy Center for Vaccine Development, Institute of Human Infections and Immunity, School of Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.
Background: Scrub typhus, a febrile illness of substantial incidence and mortality, is caused by infection with the obligately intracellular bacterium Orientia tsutsugamushi. It is estimated that there are more than one million cases annually transmitted by the parasitic larval stage of trombiculid mites in the Asia-Pacific region. The antigenic and genetic diversity of the multiple strains of O.
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