Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Improved clearance of host cell protein impurities at the polishing purification step using multimodal chromatography.
J Chromatogr A
September 2024
Purification Process Sciences, BioPharmaceuticals Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. Electronic address:
In biotherapeutic protein production, host cell proteins (HCPs) are one of the main process related impurities which must be cleared and controlled through downstream processing. In this paper, we studied a novel therapeutic protein molecule which had a high level of HCP co-purification throughout the downstream process. Here, we focused on the polishing purification step and developed an effective strategy for improving HCP clearance using multimodal chromatography (MMC) resin, Nuvia cPrime.
View Article and Find Full Text PDFKorean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission.
Chin J Nat Med
July 2024
Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University, Daejeon 34134, Korea. Electronic address:
Panax ginseng (C.A. Mey.
View Article and Find Full Text PDFPhosphorylation of cell cycle and apoptosis regulatory protein-1 by stress activated protein kinase P38γ is a novel mechanism of apoptosis signaling by genotoxic chemotherapy.
Front Oncol
May 2024
John D. Dingell V.A. Medical Center, Wayne State University, Detroit, MI, United States.
Article Synopsis
- CARP-1 is a protein that helps regulate cell survival and death in response to genotoxic drugs, but the specific kinases involved in its phosphorylation and signaling pathways are not fully understood.
- Substituting certain amino acids in CARP-1 inhibits the drug-induced apoptosis, and researchers found that the SAPK p38γ kinase specifically phosphorylates a conserved motif in CARP-1.
- By analyzing protein interactions in cancer cells, the study concludes that the phosphorylation of CARP-1 by p38γ is crucial for inhibiting cell growth when treated with genotoxic drugs, linking this to patient outcomes after treatment.
Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus.
J Agric Food Chem
October 2023
Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069, China.
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with increasing morbidity. Protein tyrosine phosphatase 1B (PTP1B) is a major negative regulator of the insulin signaling cascade and has attracted intensive investigation in the T2DM study. Ginseng is widely used to treat metabolic diseases, while the effects of ginsenoside F4 (F4) on T2DM have remained unknown.
View Article and Find Full Text PDFmA methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.
Pharmacol Res
March 2023
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing 210023, China. Electronic address:
The roles of nuclear receptor subfamily 1 group d member 1 (NR1D1) and the circadian clock in liver fibrosis remain unclear. Here, we showed that liver clock genes, especially NR1D1, were dysregulated in mice with carbon tetrachloride (CCl)-induced liver fibrosis. In turn, disruption of the circadian clock exacerbated experimental liver fibrosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!