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A Multi-centre Analysis of Serum IgE Levels in Atopic Dermatitis.
Indian J Dermatol
October 2024
From the Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Objective: To assess the characteristics of total immunoglobulin E (IgE) and allergen-specific IgE (sIgE) to 20 common allergens in 154 patients with atopic dermatitis (AD). To assess the correlation of clinical food allergy with positive food allergens' sIgE results. We further discuss the significance of IgE as a potential biomarker for AD disease severity.
View Article and Find Full Text PDFAllergic rhinitis management: a Delphi Consensus promoted by the Italian Society of Pediatric Allergy and Immunology (SIAIP).
Ital J Pediatr
November 2024
Allergy Clinic, Casa di Cura Villa Montallegro, Via Monte Zovetto, 27, Genoa, 16145, Italy.
Allergic rhinitis (AR) is the most frequent IgE-mediated disease, mainly in children and adolescents. Management of AR in the pediatric age may be heterogeneous, and the available guidelines do not adequately consider this issue. As a result, the Italian Society of Pediatric Allergy and Immunology (SIAIP) promoted a Delphi Consensus to define and evaluate the most relevant aspects of AR management in the pediatric setting in Italy.
View Article and Find Full Text PDFProbiotics and other adjuvants in allergen-specific immunotherapy for food allergy: a comprehensive review.
Front Allergy
October 2024
Pediatric Unit, Sant'Eugenio Hospital, Rome, Italy.
This review delves into the potential of manipulating the microbiome to enhance oral tolerance in food allergy, focusing on food allergen-specific immunotherapy (FA-AIT) and the use of adjuvants, with a significant emphasis on probiotics. FA-AIT, including oral (OIT), sublingual (SLIT), and epicutaneous (EPIT) immunotherapy, has shown efficacy in desensitizing patients and achieving sustained unresponsiveness (SU). However, the long-term effectiveness and safety of FA-AIT are still under investigation.
View Article and Find Full Text PDFAllergic rhinitis management: a survey on Italian primary care pediatricians.
Eur Ann Allergy Clin Immunol
October 2024
Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.
Article Synopsis
- Allergic rhinitis (AR) is common among children, prompting the Italian Society of Pediatric Allergology and Immunology to survey pediatricians about their management practices for AR.
- The survey included input from 864 primary care pediatricians, revealing that they collectively manage over 81,000 children with AR, with a majority adhering to ARIA guidelines.
- Findings show that 42% of children have mild AR while 58% have moderate to severe cases, with intranasal corticosteroids being the most frequently prescribed medication, alongside oral antihistamines and nasal lavages.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
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