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Increased Medial Temporal Tau Positron Emission Tomography Uptake in the Absence of Amyloid-β Positivity.

JAMA Neurol

October 2023

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.

Importance: An increased tau positron emission tomography (PET) signal in the medial temporal lobe (MTL) has been observed in older individuals in the absence of amyloid-β (Aβ) pathology. Little is known about the longitudinal course of this condition, and its association with Alzheimer disease (AD) remains unclear.

Objective: To study the pathologic and clinical course of older individuals with PET-evidenced MTL tau deposition (TMTL+) in the absence of Aβ pathology (A-), and the association of this condition with the AD continuum.

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An average hemisphere of the human cerebral cortex contains over 100 individual folds (sulci). Many of these sulci have been overlooked by classic and modern atlases and neuroimaging tools. These sulci also show prominent individual differences: They can be broken into variable "complexes" and some sulci may not be present altogether.

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