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Neurotoxic Effects and Cognitive Decline Induced by Aniline Blue Dye in an In-Vivo Zebrafish Model.
Toxicology
January 2025
Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu District, Tamil Nadu, India. Electronic address:
Aniline Blue is a synthetic dye extensively used in various industries, including textiles, plastics, and biological research due to its effective staining properties. However, its environmental and health impacts, particularly its neurotoxic effects, are poorly understood. While the dye has been associated with carcinogenicity and organ toxicity, the neurobehavioral consequences of Aniline Blue exposure remain underexplored.
View Article and Find Full Text PDFSpectrum and carcinogenic properties of thyroglobulin gene fusions in thyroid.
Endocr Relat Cancer
January 2025
A Nikitski, Department of Pathology, University of Pittsburgh, Pittsburgh, 15261, United States.
Approximately 10-20% of thyroid cancers are driven by gene fusions, which activate oncogenic signaling through aberrant overexpression, ligand-independent dimerization, or loss of inhibitory motifs. We identified 13 thyroid tumors with thyroglobulin (TG) gene fusions and aimed to assess their histopathology and the fusions' oncogenic and tumorigenic properties. Of 11 cases with surgical pathology, 82% were carcinomas and 18% noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP).
View Article and Find Full Text PDFAnthelmintic activity and pathophysiological effect of Allium sativum crude extract against carcinogenic liver fluke, Opisthorchis viverrini.
Trop Biomed
December 2024
Parasitic Disease Research Center, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Opisthorchis viverrini poses a substantial risk for cholangiocarcinoma (CCA) in Thailand. Despite praziquantel (PZQ) remains the primary treatment for opisthorchiasis, its association with adverse effects and potential CCA development during prolonged treatment, particularly in cases of reinfection and chronic infection, underscores the imperative for alternative herbal interventions with anthelmintic potential. In this context, a prior study suggested the inhibitory effects of Allium sativum L.
View Article and Find Full Text PDFIsolation, identification, and characterisation of the malachite green detoxifying bacterial strain Bacillus pacificus ROC1 and the azoreductase AzrC.
Sci Rep
January 2025
Department of Biotechnology, COMSATS University Islamabad, Abbottabad, Pakistan.
Malachite green (MG) is used as a dye for materials such as wood, cotton, and nylon, and is used in aquaculture to prevent fungal and protozoan diseases. However, it is highly toxic, with carcinogenic, mutagenic, and teratogenic properties, resulting in bans worldwide. Despite this, MG is still frequently used in many countries due to its efficacy and economy.
View Article and Find Full Text PDFEffect of doping in TiO/chitosan composite on adsorptive-photocatalytic removal of gallic acid from water.
Chemosphere
January 2025
Department of Chemistry, School of Chemical Engineering and Physical Sciences, Lovely professional University, Phagwara, Punjab, India. Electronic address:
Gallic acid (GA) has emerged as a low biodegradable and high acidity industrial effluent. Due to mutagenic and carcinogenic nature of GA, it becomes essential to remove it from wastewater. Different chemical, physical and biological methods are being used for this purpose.
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