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GDBr: genomic signature interpretation tool for DNA double-strand break repair mechanisms.
Nucleic Acids Res
January 2025
Department of Convergent Bioscience and Informatics, College of Bioscience and Biotechnology, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea.
Large genetic variants can be generated via homologous recombination (HR), such as polymerase theta-mediated end joining (TMEJ) or single-strand annealing (SSA). Given that these HR-based mechanisms leave specific genomic signatures, we developed GDBr, a genomic signature interpretation tool for DNA double-strand break repair mechanisms using high-quality genome assemblies. We applied GDBr to a draft human pangenome reference.
View Article and Find Full Text PDFResponse to: 'Is the practice of case-tracking a substitute for traditional feedback?'.
Med Teach
January 2025
Division of Hospital Medicine, Department of Medicine, University of California, San Francisco, CA.
Effect of Depth Band Replacement on Red, Green and Blue Image for Deep Learning Weed Detection.
Sensors (Basel)
December 2024
Institute of Mechanical Engineering and Energy Technology, Lucerne University of Applied Sciences and Arts, CH-6048 Horw, Switzerland.
Automated agricultural robots are becoming more common with the decreased cost of sensor devices and increased computational capabilities of single-board computers. Weeding is one of the mundane and repetitive tasks that robots could be used to perform. The detection of weeds in crops is now common, and commercial solutions are entering the market rapidly.
View Article and Find Full Text PDFHybrid Materials Based on Carbon Nanotubes and Tetra- and Octa-Halogen-Substituted Zinc Phthalocyanines: Sensor Response Toward Ammonia from the Quantum-Chemical Point of View.
Sensors (Basel)
December 2024
Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Lavrentiev Pr., 630090 Novosibirsk, Russia.
This paper presents the results of quantum-chemical modeling performed by the Density Functional-Based Tight Binding (DFTB) method to investigate the change in the band structure of hybrid materials based on carbon nanotubes and unsubstituted, tetra-, or octa-halogen-substituted zinc phthalocyanines upon the adsorption of ammonia molecules. The study showed that the electrical conductivity of these materials and its changes in the case of interaction with ammonia molecules depend on the position of the impurity band formed by the orbitals of macrocycle atoms relative to the forbidden energy gap of the hybrids. The sensor response of the hybrids containing halogenated phthalocyanines was lower by one or two orders of magnitude, depending on the number of substituents, compared to the hybrid with unsubstituted zinc phthalocyanine.
View Article and Find Full Text PDFWake Detection and Positioning for Autonomous Underwater Vehicles Based on Cilium-Inspired Wake Sensor.
Sensors (Basel)
December 2024
State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China.
This paper proposes a method for passive detection of autonomous underwater vehicle (AUV) wakes using a cilium-inspired wake sensor (CIWS), which can be used for the detection and tracking of AUVs. First, the characteristics of the CIWS and its working principle for detecting underwater flow fields are introduced. Then, a flow velocity sensor is used to measure the flow velocities of the "TS MINI" AUV's wake at different positions, and a velocity field model of the "TS MINI" AUV's wake is established.
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