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Innate immune receptors are differentially expressed in mice during experimental Schistosoma mansoni early infection.
Mem Inst Oswaldo Cruz
June 2024
Universidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Biologia Parasitária, Natal, RN, Brasil.
Article Synopsis
- - The study investigates how Schistosoma mansoni infection affects immune responses in three different mouse strains (BALB/c, C57BL/6, and Swiss) to understand the disease's pathogenesis.
- - Various factors, including parasite burden and immune receptor expression, were measured at different time points post-infection, revealing distinct responses among the mouse strains.
- - Findings indicate that the Swiss mice showed better survival rates and lower infection levels, while all strains exhibited unique patterns in immune receptor activation, suggesting an important relationship between early immune response and infection control.
Antiparasitic activity of nerolidol in a mouse model of schistosomiasis.
Int J Antimicrob Agents
September 2017
Núcleo de Pesquisa em Doenças Negligenciadas, Universidade Guarulhos, Praça Tereza Cristina, 229, Centro, Guarulhos, SP 07023-070, Brazil. Electronic address:
Schistosomiasis is a major public health problem worldwide, especially in poor communities. Since praziquantel is currently the only drug available to treat schistosomiasis, there is an urgent need to identify new antischistosomal drugs. Nerolidol is a sesquiterpene present as an essential oil in several plants that has been approved by the FDA.
View Article and Find Full Text PDFEfficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoni infection: a controlled trial.
Bull World Health Organ
July 2003
Department of Medical Clinics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Objective: To evaluate the therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide drugs, and to compare the accuracy of faecal examination with the accuracy of oogram in testing for Schistosoma mansoni infection.
Methods: In a triple-masked and randomized controlled trial, 106 patients infected with S. mansoni were randomly allocated to one of three statistically homogeneous groups.
Oogram studies in mice infected with Schistosoma mansoni and treated with dexamethasone.
Rev Inst Med Trop Sao Paulo
January 1995
Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Mice infected with about 90 cercariae of Schistosoma mansoni (LE strain) were treated during five consecutive days with dexamethasone (50 mg/Kg, subcutaneously), starting on the 42nd day of infection. Groups of five mice were then daily sacrificed from the first day after onset of treatment until the first day after. The perfusion of the portal system was performed and a piece of the intestine was processed for qualitative and quantitative oograms.
View Article and Find Full Text PDF[Schistosomiasis mansoni--drug treatment].
Mem Inst Oswaldo Cruz
March 1994
Departamento de Clinica Médica, Faculdade de Medicina, Univ. Federal de Minas Gerais, Belo Horizonte, Brasil.
It is the specific treatment of mansoni schistosomiasis that aims to act directed on the parasite, through chemotherapy. Constitutes fundamental indication to the treatment of schistosomiasis active forms, that is, these determined by the presence of living eggs in the feces or in material from rectal biopsy, since eventual contra indications are respected. Two are the medicaments actually used: oxamniquine, used in the single dosage of 15 mg/kg, V.
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