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Article Synopsis
  • Intraosseous hemangiomas are rare, benign tumors affecting bones, particularly the vertebrae and calvarium, which can cause complications like visual problems and deformities due to their slow growth.
  • A case study of a 10-year-old girl with a recurring giant calvarial hemangioma demonstrated the use of proton beam therapy (PBT) after previous treatments failed, showing positive results.
  • The patient tolerated the PBT well, with minor side effects, and after 14 months, there was a significant reduction in tumor size, suggesting PBT's potential as an effective treatment for difficult cases of hemangiomas in children.
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Introduction: Penttinen premature aging syndrome is caused by mutations in the PDGFRB gene. We describe the case of a 10-year-old girl with a de novo c.1994T>C variant in PDGFRB who developed multiple cranial, intracranial, and spinal manifestations, including macrocephaly, enlarged convexity subarachnoid spaces crossed by numerous vascularized arachnoid trabecule, hydrocephalus, spinal epidural lipomatosis, a low conus medullaris, calvarial thinning with large anterior fontanelle, and a skull fracture with bilateral epidural hematomas.

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Background: Common calvarial lesions include fibrous dysplasia (FD), intraosseous meningioma, osteoma, Langerhans cell histiocytosis (LCH), intraosseous hemangioma, dermoid and epidermoid cyst, and malignancy. Surgical removal with removal of the involved skull is the choice of treatment for these lesions. Previously, the skull defect was repaired using allograft, and alloplastic materials have been replaced with newer polyetheretherketone (PEEK) material, which is more resistant, biocompatible, and can be 3-dimension (3D)--printed.

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Calvarial haemangiomas are benign, vascular tumours of the skull involving parietal and frontal bones. Mostly these lesions remain asymptomatic, and present with cosmetic deformity, headache, uncommon neurological symptoms and reported as case reports and case series. The radiological appearance can range from sessile growing intradiploically to globular and the lesions may extend outwards or inwards after eroding the outer and inner tables of the skull.

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Calvarial Epithelioid Hemangioendothelioma Mimicking Osteosarcoma.

Radiol Imaging Cancer

March 2024

From the Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India (Y.S., A.G.); Department of Pathology, All India Institute of Medical Sciences, New Delhi, India (A.R.M.); and Department of Radiology, All India Institute of Medical Sciences, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, Rm No. 160D, Ansari Nagar, New Delhi 110029, India (K.R.).

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