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Hook plate fixation and tension band wiring in the treatment of Mayo type II olecranon fractures.
J Orthop Surg Res
January 2025
Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, No. 31 Xinjiekou East Street, Xicheng District, Beijing, 100035, China.
Background: Olecranon fractures account for 8 ∼ 10% of all elbow fractures and usually require surgical intervention. Tension band wiring (TBW) is considered as the standard treatment while it is associated with high re-operation rates.
Objective: This study aims to compare the functional outcomes, complications and re-operations of hook plate fixation (HPF) versus TBW in treating Mayo Type II olecranon fractures.
Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma.
J Transl Med
January 2025
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Background: HER2-targeted therapies have revolutionized the treatment of HER2-positive breast cancer patients, leading to significant improvements in tumor response rates and survival. However, resistance and incomplete response remain considerable challenges. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a novel therapeutic strategy for the management of dyslipidemia by enhancing the clearance of low-density lipoprotein cholesterol receptors, however recent evidence also shows links between PCSK9 and cancer cells.
View Article and Find Full Text PDFA child with Chronic Nonbacterial Osteomyelitis and celiac disease: accidental association or two different aspects of the same condition?
Ital J Pediatr
January 2025
Department of Pediatrics, IRCCS Policlinico San Matteo Foundation, Viale Golgi 19, Pavia, 27100, Italy.
Background: Chronic Nonbacterial Osteomyelitis (CNO) is a rare auto-inflammatory disease that mainly affects children, and manifests with single or multiple painful bone lesions. Due to the lack of specific laboratory markers, CNO diagnosis is a matter of exclusion from different conditions, first and foremost bacterial osteomyelitis and malignancies. Whole Body Magnetic Resonance (WBMR) and bone biopsy are the gold standard for the diagnosis.
View Article and Find Full Text PDFMinimally invasive internal splinting technique for acute closed Achilles tendon rupture.
J Orthop Surg Res
January 2025
Department of Orthopedics, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou Hubei, 434020, China.
Background: Although non-surgical and surgical approaches have been developed to repair acute closed Achilles tendon ruptures, the medical community still lacks a definitive consensus on which approach is superior. This study describes a new minimally invasive internal splinting technique combined with knotless anchors for the treatment of 22 patients with acute closed Achilles tendon rupture.
Methods: A retrospective study was conducted involving 22 patients with acute closed Achilles tendon rupture who were treated with a minimally invasive internal splinting technique at Jingzhou Hospital of Yangtze University between January 2022 to October 2023.
Postoperative fever following surgery for oral cancer: Incidence, risk factors, and the formulation of a machine learning-based predictive model.
BMC Oral Health
January 2025
Department of Anaesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Background: Postoperative fever (POF) is a common occurrence in patients undergoing major surgery, presenting challenges and burdens for both patients and surgeons yet. This study endeavors to examine the incidence, identify risk factors, and establish a machine learning-based predictive model for POF following surgery of oral cancer.
Methods: A total of seven hundred and twenty-seven consecutive patients undergoing radical resection of oral cancer were retrospectively investigated.
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