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Case study of a neuroendocrine tumor of uncertain origin: single-cell transcriptomics unravels potential primary location.
J Cancer Res Clin Oncol
December 2024
Moscow Clinical Scientific Center N.A. A.S. Loginov, Moscow, 111123, Russia.
Purpose: Determining the primary origin of non-organ-confined neuroendocrine tumors (NETs) for accurate diagnosis and management. Neuroendocrine tumors are rare neoplasms with diverse clinical behaviors. Determining their primary origin remains challenging in cases of non-organ-confined NETs.
View Article and Find Full Text PDFSquamous Cell Carcinoma of the Ovary: A Rare Case.
Cureus
November 2024
2nd Department of Obstetrics and Gynecology, Gynecologic Oncology Unit, Ippokrateio General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Ovarian squamous cell carcinoma (SCC) is a rare entity among primary ovarian cancers. This type of cancer typically originates from the transformation of mature cystic teratomas, commonly known as dermoid cysts, and occasionally from associations with endometriosis or Brenner's tumors. The typical clinical scenario involves presentation in postmenopausal women, with symptoms arising from tumor growth or metastasis.
View Article and Find Full Text PDFGenomic characterization and histologic analysis of uterine leiomyosarcoma arising from leiomyoma with bizarre nuclei.
J Pathol
December 2024
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with a benign clinical course. In contrast, leiomyosarcoma (LMS) is a high-grade, malignant neoplasm characterized by high recurrence rates and poor survival. While LM-BN and LMS show distinct morphologies, they share similar immunoprofiles and molecular alterations, with both considered 'genomically unstable'.
View Article and Find Full Text PDF[Cardiac myxoma: biological features, morphology, differential diagnosis].
Arkh Patol
December 2024
Cancer Research Institute, branch of Tomsk National Research Medical Center, Tomsk, Russia.
Cardiac myxoma in its morphology is a typical benign tumor, meanwhile, the fact of its localization in the heart chamber, directly in the constant blood flow, largely determines the clinical behavior of this neoplasm, which is often manifested by the development of characteristics that formally determine the aggressive and even malignant nature of the course. Accordingly, the malignancy of cardiac myxoma is determined more by its clinical behavior (recurrence, multifocality of the lesion, the presence of mechanisms of spread similar to metastasis) rather than by its histological picture. In the structure of primary benign tumors of the heart, myxoma occupies a dominant position and its incidence is up to 85%.
View Article and Find Full Text PDFThe role of hormone dosages in the assessment of cervical lesions by FNA: A descriptive analysis of 762 cases.
Clinics (Sao Paulo)
December 2024
Department of Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil; Managing Partner of Lab. Diagcel, São Paulo, SP, Brazil.
Introduction: The use of Hormone Dosage (HD) in Fine Needle Aspiration Biopsy (FNA) needle washout fluid, introduced in the 1990s, initially aimed at measuring Thyroglobulin (TG). Elevated TG concentration in an extrathyroidal cervical lesion suggests metastases of Well-Differentiated Thyroid Carcinomas (WDTC). Over the years, HD has evolved to incorporate Calcitonin (CT) and Parathormone (PTH), improving sensitivity and specificity in diverse clinical scenarios.
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