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Altered Cellular Metabolism Is a Consequence of Loss of the Ataxia-Linked Protein Sacsin.
Int J Mol Sci
December 2024
William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Mitochondrial dysfunction is implicated in the pathogenesis of the neurological condition autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), yet precisely how the mitochondrial metabolism is affected is unknown. Thus, to better understand changes in the mitochondrial metabolism caused by loss of the sacsin protein (encoded by the SACS gene, which is mutated in ARSACS), we performed mass spectrometry-based tracer analysis, with both glucose- and glutamine-traced carbon. Comparing the metabolite profiles between wild-type and sacsin-knockout cell lines revealed increased reliance on aerobic glycolysis in sacsin-deficient cells, as evidenced by the increase in lactate and reduction of glucose.
View Article and Find Full Text PDFShikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds.
World J Diabetes
December 2024
School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, Zhejiang Province, China.
Background: Shikonin is a natural remedy that is effective at treating diabetic wounds. NFAT5 is a potential therapeutic target for diabetes, and mitochondrial function is essential for wound healing. However, the relationship among Shikonin, NFAT5, and mitochondrial function has not been thoroughly studied.
View Article and Find Full Text PDFProlotherapy in the Treatment of Sports-Related Tendinopathies: A Systematic Review of Randomized Controlled Trials.
Orthop J Sports Med
November 2024
Department of Orthopedics and Rehabilitation, Stony Brook University Hospital, Stony Brook, New York, USA.
Background: As sports have increased in popularity, the incidence of tendinopathy has also grown dramatically. Nonoperative techniques and treatments used to address these pathologies continue to evolve and improve. One such treatment, prolotherapy (PrT), has become increasingly popular and may provide patients with an alternative nonoperative treatment option.
View Article and Find Full Text PDFHypertonic Dextrose Prolotherapy Injection in Grade IV Knee Osteoarthritis with Obesity: A Case Report.
Acta Med Indones
July 2024
Physical Medicine and Rehabilitation Specialization Program, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
The main complaint in knee osteoarthritis (KOA) is knee pain and limited range of motion (ROM) which affects the patient's quality of life. Dextrose prolotherapy successfully reduced pain and enhanced functional status and quality of life in chronic knee pain, which is classified as KOA grade II or III by the Kellgren-Lawrence classification. We present a case of grade IV KOA with co-morbid obesity who refused surgical management but got dextrose prolotherapy instead.
View Article and Find Full Text PDFTargeting Sodium in Heart Failure.
J Pers Med
October 2024
Department of Cardiology, University Hospital of Larissa, 41110 Larissa, Greece.
A dominant event determining the course of heart failure (HF) includes the disruption of the delicate sodium (Na) and water balance leading to (Na) and water retention and edema formation. Although incomplete decongestion adversely affects outcomes, it is unknown whether interventions directly targeting (Na), such as strict dietary (Na) restriction, intravenous hypertonic saline, and diuretics, reverse this effect. As a result, it is imperative to implement (Na)-targeting interventions in selected HF patients with established congestion on top of quadruple therapy with angiotensin receptor neprilysin inhibitor, β-adrenergic receptor blocker, mineralocorticoid receptor antagonist, and sodium glucose cotransporter 2 inhibitor, which dramatically improves outcomes.
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