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Volume kinetic analysis of 2 crystalloid fluid bolus rates in anesthetized cats.
J Vet Emerg Crit Care (San Antonio)
January 2025
J. T. Vaughan Large Animal Teaching Hospital, Auburn University, Auburn, Alabama, USA.
Objective: To investigate the volume kinetic between 2 crystalloid fluid bolus rates in anesthetized cats.
Design: Prospective, randomized, dose-response study.
Setting: University laboratory.
Cathinone metabolism and biliary excretion in an ex-vivo pig liver model: Example of 4-Cl-PVP and eutylone.
Food Chem Toxicol
January 2025
INSERM, Univ Rennes, INRAE, Institut NUMECAN (Nutrition, Métabolismes et Cancer) UMR_A 1341, UMR_S 1317, F-35000, Rennes, France; Laboratoire de toxicologie biologique et Médico-légale, CHU Rennes, Rennes, France.
Objective: Recently, the pig liver model perfused ex vivo using a normothermic machine perfusion (NMP) has been proposed as a suitable model to study xenobiotic metabolism and biliary excretion. The aim of our study is to describe the metabolism of NPS such as cathinones (with a focus on 4-Cl-PVP and eutylone) in blood and bile, using a normothermic perfused pig liver model.
Methods: Livers (n = 4) from male large white pigs, 3-4 months of age and weighing approximately 75-80 kg, were harvested and reperfused onto an NMP (LiverAssist®, XVIVO) using autologous whole blood at 38 °C.
Mechanical properties of snake skin vary longitudinally, following large prey ingestion and among species.
J Exp Biol
December 2024
Department of Ecology, Evolution, and Organismal Biology, Brown University, Providence, RI 02912, USA.
The ability for snakes to ingest large prey (macrostomy) is a widespread, derived trait that involves distending the skin during ingestion and metabolic upregulation during digestion. The material behavior of the skin must accommodate significant stretch associated with a large prey bolus, but data remain sparse for how the material properties of snake skin vary: longitudinally within an individual, after ingesting large prey and among species. To test whether these three factors affected the mechanical properties of snake skin, we quantified uniaxial stresses and strains in circumferential loops of skin from the neck, mid-body and tail of fasted and recently fed Boa constrictor.
View Article and Find Full Text PDFBackground: Cannabis is increasingly used and debates about the legalisation of the recreational use of cannabis are ongoing. In this prospective, placebo-controlled study in healthy volunteers not regularly consuming cannabis, subjective psychotropic and somatic effects after a single dose of intravenous THC were assessed and quantified over 48 h.
Methods: Twenty-five healthy volunteers received a single IV bolus of THC and 6 received normal saline.
ENA-001 Reverses Xylazine/Fentanyl Combination-Induced Respiratory Depression in Rats: A Qualitative Pilot Study.
Cureus
November 2024
Research and Development, Enalare Therapeutics, Princeton, USA.
Xylazine exacerbates the respiratory depression induced by fentanyl. Because xylazine is a non-opioid, it is resistant to reversal by opioid receptor antagonists such as naloxone (e.g.
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