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Ranking the risks of eighty pharmaceuticals in surface water of a megacity: A multilevel optimization strategy.
Sci Total Environ
June 2023
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China. Electronic address:
Pharmaceuticals in freshwater posed ecological risks to aquatic ecosystem, however, most risk assessments of pharmaceuticals were conducted at screening level, which were limited by the availability of the toxicity data. In this study, risks of 80 pharmaceuticals including 35 antibiotics, 13 antiviral drugs, 13 illicit drugs, and 19 antidepressants in surface water of Beijing were assessed with a proposed multilevel environmental risk optimization strategy. Target pharmaceuticals were detected in surface water samples with the detection frequency from 1.
View Article and Find Full Text PDFInvestigation of Chloroquine Resinate Feasibility and In Vitro Taste Masking Evaluation for Pediatric Formulations.
AAPS PharmSciTech
February 2022
Laboratório de Farmacotécnica Experimental, Instituto de Tecnologia em Fármacos (Famanguinhos), FIOCRUZ, Rua Sizenando Nabuco 100 - Manguinhos., Rio de Janeiro, RJ, Brazil.
In this study, chloroquine resinates were prepared at a 1:1 (w:w) drug-to-resin ratio using the batch method with polacrilex (PC), sodium polystyrene sulfonate (SPS), and polacrilin potassium (PP) ion exchange resins (IER). The influence of drug/resin ratio and pH of the medium on drug loading efficiency was explored. UV-VIS spectrophotometric analysis showed that SPS resin had high loading efficiency for chloroquine diphosphate (CLP), above 89%, regardless of the pH.
View Article and Find Full Text PDFCo-delivery of autophagy inhibitor and gemcitabine using a pH-activatable core-shell nanobomb inhibits pancreatic cancer progression and metastasis.
Theranostics
February 2022
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China.
Metastasis is one of the main reasons for the high mortality associated with pancreatic ductal adenocarcinoma (PDAC), and autophagy regulates the metastatic migration of tumor cells, their invasion of tissues, and their formation of focal adhesions. Inhibiting autophagy may suppress tumor growth and metastasis, but the abundant extracellular matrix hinders the deep penetration of therapeutic agents. To enhance the penetration of drugs that can inhibit metastasis of pancreatic cancer, a pH-responsive drug delivery system was formulated.
View Article and Find Full Text PDFRisk factors for prolonged virus shedding of respiratory tract and fecal in adults with severe acute respiratory syndrome coronavirus-2 infection.
J Clin Lab Anal
September 2021
Department of Experimental Medical Science, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Background: The dynamic alteration and comparative study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA shedding pattern during treatment are limited. This study explores the potential risk factors influencing prolonged viral shedding in COVID-19.
Methods: A total of 126 COVID-19 patients were enrolled in this retrospective longitudinal study.
Clinical characteristics of COVID-19 patients hospitalized at Clinique Ngaliema, a public hospital in Kinshasa, in the Democratic Republic of Congo: A retrospective cohort study.
PLoS One
January 2021
Clinique Ngaliema, Kinshasa, République Démocratique du Congo.
Article Synopsis
- The study aimed to analyze the clinical characteristics of 160 hospitalized COVID-19 patients at a public hospital in Kinshasa, DRC, focusing on demographics, symptoms, and outcomes.
- Findings revealed a median patient age of 54, with common comorbidities like hypertension (34%), diabetes (19%), and obesity (8%), and prevalent symptoms including fever (58%), cough (57%), and fatigue (54%).
- The research identified older age, lower oxygen levels, higher heart rate, and elevated AST as key risk factors for in-hospital death, with a very low prevalence of malaria co-infection among these patients.
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