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Etoposide-loaded lipopolymer nanoparticles promote Smac minetic activity against inhibitor of apoptosis protein for glioblastoma treatment.
Biomater Adv
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Department of Biomedical Sciences, National Chung Cheng University, Chia-Yi 62102, Taiwan, ROC.
Encapsulated BV6 and SM164, two bivalent second mitochondria-derived activator of caspase (Smac) mimetics, in etoposide (ETO)-lipopolymer nanoparticles (NPs) have been developed to deplete inhibitor of apoptosis proteins (IAP), impair DNA, and produce antagonistic effects on glioblastoma multiforme (GBM) in nude mice. The NPs, composed of cocoa butter (CB) and polyvinyl alcohol (PVA), were stabilized by glycerol monostearate and Pluronic F-127, and grafted with transferrin (Tf) and wheat germ agglutinin (WGA) to dock the blood-brain barrier (BBB) and degenerated dopaminergic neurons. The dual-targeting NPs increased the BBB permeability of BV6, SM164 and ETO via recognizing Tf receptor (TfR) and N-acetylglucosamine that are abundantly expressed on brain microvascular endothelial cells.
View Article and Find Full Text PDFOptimization of mechanical and water barrier properties of avocado seed starch based film and its application as smart pH indicator by adding blue butterfly pea flower extract.
Food Chem X
January 2025
Istanbul Aydin University, Engineering Faculty, Food Engineering Department, 34295 Istanbul, Türkiye.
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View Article and Find Full Text PDFDevelopment of edible films based on sweet potato (Ipomoea batatas) starch and their application in candy packaging.
Int J Biol Macromol
January 2025
Department Food Engineering, Universidad de Córdoba, Montería, Colombia. Electronic address:
Recent studies have focused on the generation of biomaterials from natural sources, highlighting the use of starch from different sources to obtain edible films and coatings. In this study, edible films were developed from sweet potato starch, and their potential use in candy packaging was evaluated. Films were prepared by the casting method, and the effects of sweet potato starch (3 %-5 % w/w), glycerol (0.
View Article and Find Full Text PDFInfluence of alginate extraction conditions from the brown seaweed Dictyota mertensii on the functional properties of a novel glycerol plasticized alginate film.
Carbohydr Polym
March 2025
Department of Engineering and Technology, Universidade Federal Rural do Semi-Árido, Mossoró Campus, Mossoró 59625-900, Rio Grande do Norte, Brazil.
Alginate films were prepared from the brown seaweed Dictyota mertensii using glycerol as a plasticizer. The effects of extraction conditions-time, temperature, and NaCO concentration-on the optical, barrier, and mechanical properties of the films were investigated using a central composite design (CCD). ANOVA and F tests confirmed the models' statistical significance at p ≤ 0.
View Article and Find Full Text PDFInactivation activity and mechanism of high-voltage pulsed electric fields combined with antibacterial agents against Alicyclobacillus spp. in apple juice.
Int J Food Microbiol
January 2025
College of Food Science and Engineering, Northwest University, Xi'an, Shaanxi 710069, China. Electronic address:
Alicyclobacillus spp. are crucial factors affecting the quality of fruit juice, so it is very important to control their contamination. In this study, the inactivation activity and mechanism of high-voltage pulsed electric fields (HVPEF) combined with antibacterial agents against Alicyclobacillus spp.
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