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Using a Theoretical Model to Assess the Impact of Vascular Risk Factors on Autoregulation in the Retina.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai Hospital, New York, New York, United States.
Purpose: Vascular impairments, including reduced capillary density (CD), impaired autoregulation capacity (Reg), and elevated intraocular pressure (IOP), have been identified as significant contributors to glaucomatous disease. This study implemented a theoretical model to quantify the impact of these impairments on retinal blood flow and oxygenation as intraluminal pressure (Pa) is varied.
Methods: A theoretical model of the retinal vasculature was used to simulate reductions in CD by 10% (early glaucoma) and 30% to 50% (advanced glaucoma), a range in autoregulation capacity from 0% (totally impaired) to 100% (totally functional), and normal (15 mm Hg) and elevated (25 mm Hg) levels of IOP.
Upconverting microgauges reveal intraluminal force dynamics in vivo.
Nature
January 2025
Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
The forces generated by action potentials in muscle cells shuttle blood, food and waste products throughout the luminal structures of the body. Although non-invasive electrophysiological techniques exist, most mechanosensors cannot access luminal structures non-invasively. Here we introduce non-toxic ingestible mechanosensors to enable the quantitative study of luminal forces and apply them to study feeding in living Caenorhabditis elegans roundworms.
View Article and Find Full Text PDFIntraluminal Insertion of 9-0 Nylon for Postoperative Choroidal Detachment After Preserflo MicroShunt Implantation: A Case Report.
Cureus
November 2024
Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JPN.
Preserflo MicroShunt (PMS) implantation is a minimally invasive surgical procedure for treating glaucoma. Postoperative hypotony, a common complication of PMS implantation, can be prevented and treated with 10-0 nylon insertion. In this report, we present a case of postoperative hypotony following PMS implantation that was treated with intraluminal insertion of 9-0 nylon.
View Article and Find Full Text PDFManagement of Infected Dentigerous Cyst in an 8-year-old Patient Using Decompression Technique: A Case Report and Review of Literature.
Int J Clin Pediatr Dent
October 2024
Department of Public Health Dentistry, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, Maharashtra, India.
Article Synopsis
- Odontogenic cysts can be treated aggressively through enucleation or conservatively through techniques like cyst decompression.
- Cyst decompression helps to alleviate pressure within the cyst, leading to its shrinkage and potentially avoiding more invasive treatments.
- The article details a case study of an 8-year-old boy with an infected odontogenic cyst who underwent a decompression technique for treatment.
Nonoperative Management of Boerhaave Syndrome: A Case Study.
Cureus
October 2024
4th Department of Surgery, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Spontaneous esophageal rupture, also known as Boerhaave syndrome, represents an unusual yet clinically significant condition characterized by the rupture of the esophageal wall due to a sudden increase in intraluminal pressure, typically induced by vomiting, concomitant with negative intrathoracic pressure dynamics. This condition poses a challenging clinical entity, presenting high mortality rates, especially when treatment is delayed. Surgical intervention is frequently employed as the primary management strategy, while non-surgical approaches, including stent placement and endoluminal vacuum therapy, are less commonly utilized.
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