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Evaluating the sustained effectiveness of a novel pharmacy-based intervention to reduce older adult misuse of over-the-counter medications: A case for non-significance.
Res Social Adm Pharm
January 2025
Division of Social and Administrative Sciences & Sonderegger Research Center for Improved Medication Outcomes, University of Wisconsin-Madison School of Pharmacy, 777 Highland Avenue, Madison, WI, 53705, USA. Electronic address:
Introduction: Misuse of over-the-counter (OTC) medications by older adults (age 65+) can comprise Drug-Age, Drug-Drug, Drug-Disease, and Drug-Label types. Pharmacies in the United States are prevalent sources of OTCs and are an apt setting to address OTC misuse. Senior Safe™ is a pharmacy-system redesign for preventing older adult OTC misuse.
View Article and Find Full Text PDFTwo decades of bacterial ecology and evolution in a freshwater lake.
Nat Microbiol
January 2025
Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA.
Ecology and evolution are considered distinct processes that interact on contemporary time scales in microbiomes. Here, to observe these processes in a natural system, we collected a two-decade, 471-metagenome time series from Lake Mendota (Wisconsin, USA). We assembled 2,855 species-representative genomes and found that genomic change was common and frequent.
View Article and Find Full Text PDFTimeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study.
Lancet Neurol
December 2024
Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; School of Human Ecology, University of Wisconsin-Madison, Madison, WI, USA. Electronic address:
Article Synopsis
- This study focused on the risk of Alzheimer's disease in adults with Down syndrome, using amyloid and tau PET imaging to track disease progression.
- It involved a longitudinal analysis of 167 participants, assessing cognitive functioning and biomarkers over two visits between 2017 and 2022.
- The research aimed to determine the timeline for symptomatic Alzheimer's based on "amyloid age" and its relation to cognitive decline and tau accumulation.
The Impact of Early Exposure to Microsurgery Training on Undergraduates: A Pilot Course.
WMJ
November 2024
Division of Plastic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin,
Introduction: This case study aimed to investigate a disparity in the medical education pipeline by investigating the impact of fundamental microsurgical training on interest and desire to pursue a career in medicine. This research introduces a method to attract undergraduate students from various backgrounds to the field of microsurgery through a hands-on microsurgical training course.
Methods: Microsurgical training took place 6 hours a week for 6 weeks.
Renal autotransplant as a definitive treatment for nutcracker syndrome: A multicenter retrospective study.
J Vasc Surg Venous Lymphat Disord
January 2025
Department of Surgery-Transplant Surgery, University of Colorado School of Medicine, Aurora, CO.
Objective: Nutcracker syndrome is a rare condition that involves mechanical compression of the left renal vein, leading to chronic and debilitating left flank pain. The etiology of the pain is misdiagnosed frequently, and patients usually require long-term opioid use to manage their pain. Multiple therapeutic options for nutcracker syndrome have been described in the literature but the reports are limited by small numbers of patients, and the lack of convincing data demonstrating consistently improved outcomes.
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