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A conformational switch-controlled RNA sensor based on orthogonal dCas12a for RNA imaging in live cells.
Biosens Bioelectron
January 2025
Lab of Biosystem and Microanalysis, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, Shanghai, 200237, China; School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang, 832000, China. Electronic address:
RNA imaging technology is essential for understanding the complex RNA regulatory mechanisms and serves as a powerful tool for disease diagnosis. However, conventional RNA imaging methods often require multiple fluorescent tags for the specific labeling of individual targets, complicating both the imaging process and subsequent analysis. Herein, we develop an RNA sensor that integrates a blocked CRISPR RNA (crRNA)-based conformational switch with a controllable CRISPR activation (CRISPRa) system and apply for RNA imaging.
View Article and Find Full Text PDFPortable paper-based microfluidic devices based on CuS@AgS nanocomposites for colorimetric/electrochemical dual-mode detection of dopamine.
Biosens Bioelectron
January 2025
Centre for Advanced Optoelectronic Functional Materials Research and Key Laboratory of UV Light-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, 130024, Changchun, China. Electronic address:
The development of integrated multiple signal outputs within a single platform is highly significant for efficient and accurate on-site biomarker detection. Herein, colorimetric/electrochemical dual-mode microfluidic paper-based analytical devices (μPADs) were designed for portable, visual and accurate dopamine (DA) detection. The dual-mode μPADs, featuring folded structure, integrate a colorimetric layer and an electrochemical layer using wax printing and laser-induced graphene (LIG) pyrolysis techniques, allowing the vertical flow of analyte solution.
View Article and Find Full Text PDFObsessive-compulsive symptoms and personal recovery in patients with schizophrenia spectrum disorders: A cross-sectional study.
Schizophr Res
January 2025
Department of Psychiatry, Amsterdam UMC, Amsterdam, the Netherlands; Arkin Institute for Mental Health, Amsterdam, the Netherlands.
Background: Obsessive-compulsive symptoms (OCS) frequently co-occur in patients with Schizophrenia Spectrum Disorders (SSD). Patients with SSD and OCS experience increased clinical and social challenges, including diminished quality of life and subjective well-being. However, it is unknown whether co-morbid OCS are associated with personal recovery.
View Article and Find Full Text PDFBuilding resilience: A promising approach to reduce anxiety in mothers and hospitalized children with burn injuries.
Burns
January 2025
Department of Nursing, School of Nursing and Midwifery, Islamic Azad University, Kazerun, Iran.
The psychological impact of pediatric burn injuries is profound, often resulting in elevated levels of anxiety for both children and their mothers. This quasi-experimental study was conducted to explore the effectiveness of a resilience training program aimed at reducing anxiety among mothers and their hospitalized children with burn injuries at a burn hospital in Shiraz, Iran. Fifty-six eligible mothers were initially selected through purposive sampling and assigned to either the experimental or control group in a 1:1 ratio through random assignment.
View Article and Find Full Text PDFKinematic Alignment Does Not Result in Clinically Important Improvements After TKA Compared With Mechanical Alignment: A Meta-analysis of Randomized Trials.
Clin Orthop Relat Res
January 2025
Division of Orthopaedic Surgery, University of Toronto, Toronto, ON, Canada.
Background: There is debate as to whether kinematic TKA or mechanical alignment TKA is superior. Recent systematic reviews have suggested that kinematically aligned TKAs may be the preferred option. However, the observed differences in alignment favoring kinematic alignment may not improve outcomes (performance or durability) in ways that patients can perceive, and likewise, statistical differences in outcome scores sometimes observed in clinical trials may be too small for patients to notice.
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