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Exploration the effective components of Gastrodia elata in improving cerebral ischemia reperfusion injury based on "Spectrum-effect" correlation and zebrafish verification experiment.
Phytomedicine
December 2024
School of pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, PR China; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, PR China; Resources Protection and Development Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, PR China; Anhui Province Key Laboratory of Traditional Chinese Medicine Decoction Pieces of New Manufacturing Technology, Bozhou, PR China. Electronic address:
Background: Gastrodia elata (GE) has been widely used in clinical practice for many years with the functions of relieving stroke, suppressing liver Yang, dispelling wind and clearing collaterals. Our group's previous experimental studies have proved that GE has therapeutic effect on cerebral ischemia reperfusion injury (CIRI) (Ding et al., 2022).
View Article and Find Full Text PDFSafe Endovascular Recanalization of Internal Carotid Artery Occlusion Using Retrograde Aspiration Angiography.
World Neurosurg
December 2024
Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Article Synopsis
- Cerebral infarction due to internal carotid artery occlusion can lead to severe symptoms; treatment options include mechanical thrombectomy within 24 hours or conservative approaches for mild cases with collateral circulation.
- In cases where symptoms worsen, superficial temporal artery - middle cerebral artery anastomosis may be employed for revascularization, verified with contralateral angiography.
- Ten acute ICA occlusion cases were treated using intermediate catheter technology, achieving successful recanalization without significant complications, highlighting the method's effectiveness.
Cementless, Cruciate-Retaining Primary Total Knee Arthroplasty Using Conventional Instrumentation: Technical Pearls and Intraoperative Considerations.
JBJS Essent Surg Tech
September 2024
Department of Orthopaedic Surgery, The Johns Hopkins Hospital, Baltimore, Maryland.
Article Synopsis
- Total knee arthroplasty (TKA) is a common surgical procedure for patients with severe knee osteoarthritis, especially when non-surgical treatments fail, leading to significant improvements in pain, function, and quality of life.
- The procedure can use various components (cemented, cementless, or a hybrid) and is generally performed with a focus on mechanical alignment, although newer alignment strategies like gap and kinematic balancing are showing promising results in early studies.
- The preferred surgical technique for cementless TKA involves a specific patient positioning and incision approach, starting with the application of a thigh tourniquet and a parapatellar incision, ensuring proper alignment and access during the surgery.*
Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV).
Commun Biol
July 2024
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore.
R-loop-triggered collateral single-stranded DNA (ssDNA) nuclease activity within Class 1 Type I CRISPR-Cas systems holds immense potential for nucleic acid detection. However, the hyperactive ssDNase activity of Cas3 introduces unwanted noise and false-positive results. In this study, we identified a novel Type I-A Cas3 variant derived from Thermococcus siculi, which remains in an auto-inhibited state until it is triggered by Cascade complex and R-loop formation.
View Article and Find Full Text PDF[Mechanism and compatibility efficacy of Astragali Radix-Chuanxiong Rhizoma drug pair in treating ischemic stroke based on network regulation].
Zhongguo Zhong Yao Za Zhi
May 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Based on the association network of "drug pair-disease", the effect characteristics of Astragali Radix-Chuanxiong Rhizoma drug pair in the treatment of ischemic stroke(IS) with Qi deficiency and blood stasis and the matching mechanism of the two were explored. Through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) and SwissTargetPrediction Database, the effective chemical components of the drug pair were screened, and the candidate targets were predicted. Databa-ses such as GeneCards, DrugBank, Online Mendelian Inheritance in Man(OMIM), and Therapeutic Target Database(TTD) were searched to obtain gene targets related to IS.
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