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Role of bone morphogenetic protein signaling in bovine early embryonic development and stage specific embryotropic actions of follistatin†.
Biol Reprod
April 2020
Laboratory of Mammalian Reproductive Biology and Genomics, Michigan State University, East Lansing, Michigan, USA.
Characterization of the molecular factors regulating early embryonic development and their functional mechanisms is critical for understanding the causes of early pregnancy loss in monotocous species (cattle, human). We previously characterized a stage specific functional role of follistatin, a TGF-beta superfamily binding protein, in promoting early embryonic development in cattle. The mechanism by which follistatin mediates this embryotropic effect is not precisely known as follistatin actions in cattle embryos are independent of its classically known activin inhibition activity.
View Article and Find Full Text PDFPre- and Peri-/Post-Compaction Follistatin Treatment Increases In Vitro Production of Cattle Embryos.
PLoS One
August 2017
Laboratory of Mammalian Reproductive Biology and Genomics, Michigan State University, East Lansing, MI, United States of America.
Our previous studies demonstrated that maternal (oocyte derived) follistatin (FST) expression is positively associated with bovine oocyte competence and exogenous follistatin treatment during the pre-compaction period of development (d 1-3 post insemination) is stimulatory to bovine early embryogenesis in vitro [blastocyst rates and cell numbers/allocation to trophectoderm (TE)]. In the present study, bovine embryos were treated with exogenous follistatin during d 1-3, d 4-7 and d 1-7 post insemination to test the hypothesis that embryotropic effects of exogenous follistatin are specific to the pre-compaction period (d 1-3) of early embryogenesis. Follistatin treatment during d 4-7 (peri-/post-compaction period) of embryo culture increased proportion of embryos reaching blastocyst and expanded blastocyst stage and total cell numbers compared to controls, but blastocyst rates and total cell numbers were lower than observed following d 1-3 (pre-compaction) follistatin treatment.
View Article and Find Full Text PDFEvidence supporting a role for SMAD2/3 in bovine early embryonic development: potential implications for embryotropic actions of follistatin.
Biol Reprod
October 2015
Laboratory of Mammalian Reproductive Biology and Genomics, Michigan State University, East Lansing, Michigan Department of Animal Science, Michigan State University, East Lansing, Michigan Department of Physiology, Michigan State University, East Lansing, Michigan
The TGF-beta-SMAD signaling pathway is involved in regulation of various aspects of female reproduction. However, the intrinsic functional role of SMADs in early embryogenesis remains poorly understood. Previously, we demonstrated that treatment with follistatin, an activin (TGF-beta superfamily ligand)-binding protein, is beneficial for bovine early embryogenesis and specific embryotropic actions of follistatin are dependent on SMAD4.
View Article and Find Full Text PDFThe regulation of the expression and activation of the essential ATF1 transcription factor in the mouse preimplantation embryo.
Reproduction
August 2014
Sydney Medical SchoolKolling Institute for Medical Research, Centre for Developmental and Regenerative Medicine, University of Sydney, Sydney, New South Wales 2065, Australia
The co-expression of the CREB and ATF1 transcription factors is required for the development of preimplantation embryos. Embryotropin-mediated, calcium/calmodulin-dependent signalling activates CREB-induced transcription in the two-cell embryo, but the regulation of ATF1 in the embryo is not known. This study demonstrates that ATF1 begins to accumulate within both pronuclei of the mouse zygote by 20 h post-human chorionic gonadotrophin.
View Article and Find Full Text PDFEmbryotropic actions of follistatin: paracrine and autocrine mediators of oocyte competence and embryo developmental progression.
Reprod Fertil Dev
August 2014
Laboratory of Mammalian Reproductive Biology and Genomics, Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA.
Despite several decades since the birth of the first test tube baby and the first calf derived from an in vitro-fertilised embryo, the efficiency of assisted reproductive technologies remains less than ideal. Poor oocyte competence is a major factor limiting the efficiency of in vitro embryo production. Developmental competence obtained during oocyte growth and maturation establishes the foundation for successful fertilisation and preimplantation embryonic development.
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