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Calcium Pyrophosphate Crystal Deposition: Insights to Risks Factors and Associated Conditions.
Curr Rheumatol Rep
November 2024
University of Cyprus Medical School, Nicosia, Cyprus.
Article Synopsis
- The review focuses on CPPD (Calcium pyrophosphate deposition disease), outlining its medical conditions and risk factors, particularly in older adults.
- Recent studies highlight a connection between CPPD and systemic conditions, notably an increased risk of cardiovascular diseases along with associations to other metabolic and endocrine disorders.
- There is a need for further research to understand the mechanisms behind these associations and to create targeted therapies for better patient outcomes.
Calcium pyrophosphate deposition disease.
Lancet Rheumatol
November 2024
Academic Rheumatology, University of Nottingham, Nottingham, UK; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Article Synopsis
- - Calcium pyrophosphate deposition disease (CPPD) occurs when CPP crystals build up in joints, triggering inflammation and arthritis, particularly in older individuals over 60, and is linked to cartilage deterioration and osteoarthritis.
- - Common risk factors for CPPD include aging, past joint injuries, and certain metabolic conditions or genetic factors. Diagnosis relies on detecting CPP crystals in joint fluid and imaging techniques like X-rays and ultrasound.
- - Current treatment focuses on managing inflammation since there’s no cure for dissolving CPP crystals; options include prednisone for acute arthritis, low-dose colchicine, and potential use of biologics for stubborn cases.
A Narrative Review of Chondrocalcinosis: Clinical Presentation, Diagnosis, and Therapies.
Cureus
May 2024
Rheumatology, Loma Linda University Health, Loma Linda, USA.
Article Synopsis
- Calcium pyrophosphate deposition disease (CPPD) includes conditions like chondrocalcinosis and different types of arthritis characterized by pain and swelling in joints due to calcium deposits, often triggered by genetic and health factors like primary hyperparathyroidism.
- Symptoms vary: radiographic chondrocalcinosis is usually asymptomatic, while acute arthritis causes sudden pain and swelling, and chronic arthritis leads to intermittent flare-ups similar to acute episodes.
- Guidelines developed in 2023 help identify CPPD; diagnosis relies on evidence from imaging or synovial fluid analysis, and treatments aim to manage flares, using options like NSAIDs, colchicine, and corticosteroids.
Hemochromatosis: Ferroptosis, ROS, Gut Microbiome, and Clinical Challenges with Alcohol as Confounding Variable.
Int J Mol Sci
February 2024
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, D-63450 Hanau, Germany.
Hemochromatosis represents clinically one of the most important genetic storage diseases of the liver caused by iron overload, which is to be differentiated from hepatic iron overload due to excessive iron release from erythrocytes in patients with genetic hemolytic disorders. This disorder is under recent mechanistic discussion regarding ferroptosis, reactive oxygen species (ROS), the gut microbiome, and alcohol abuse as a risk factor, which are all topics of this review article. Triggered by released intracellular free iron from ferritin via the autophagic process of ferritinophagy, ferroptosis is involved in hemochromatosis as a specific form of iron-dependent regulated cell death.
View Article and Find Full Text PDFJoint manifestations revealing inborn metabolic diseases in adults: a narrative review.
Orphanet J Rare Dis
August 2023
Department of Internal Medicine, University Hospital of Tours, Tours, France.
Inborn metabolic diseases (IMD) are rare conditions that can be diagnosed during adulthood. Patients with IMD may have joint symptoms and the challenge is to establish an early diagnosis in order to institute appropriate treatment and prevent irreversible damage. This review describes the joint manifestations of IMD that may be encountered in adults.
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