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A further unique chondroitin sulfate from the shrimp Litopenaeus vannamei with antithrombin activity that modulates acute inflammation.
Carbohydr Polym
October 2019
Programa de Pós-graduação em Bioquímica e Biologia Molecular, Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. Electronic address:
The detailed structure of a further Chondroitin Sulfate from Litopenaeus vannamei shrimp (sCS) is described. The backbone structure was established by H/C NMR, which identified 3-O-sulfated GlcA, 4-O-sulfated GalNAc, 6-O-sulfated GalNAc, and 4,6-di-O-sulfated GalNAc residues. GlcA is linked to GalNAc 4,6 di S and GlcA 3S is linked to GalNAc 4S, GalNAc 4,6 di-S and GalNAc6S residues.
View Article and Find Full Text PDFSalmon Protamine Decreases Serum and Liver Lipid Contents by Inhibiting Lipid Absorption in an In Vitro Gastrointestinal Digestion Model and in Rats.
J Food Sci
October 2015
Lab. of Food and Nutritional Sciences, Faculty of Chemistry, Materials, and Bioengineering, Kansai Univ, Suita, Osaka, 564-8680, Japan.
Protamine has been used as an antiheparin drug and a natural preservative in various food products. However, limited studies have evaluated the physicochemical and functional properties of protamine. Hence, we assessed the mechanisms underlying the inhibition of lipid absorption following salmon protamine intake in in vitro and in vivo studies.
View Article and Find Full Text PDFA phase I pharmacological and biological study of PI-88 and docetaxel in patients with advanced malignancies.
Cancer Chemother Pharmacol
December 2008
University of Colorado Heath Sciences Center, Aurora, CO, USA.
Purpose: This study evaluated the safety, toxicity, pharmacological properties and biological activity of PI-88, a heparanase endoglycosidase enzyme inhibitor, with fixed weekly docetaxel in patients with advanced solid malignancies.
Experimental Design: This was a phase I study to determine the maximal-tolerated dose of escalating doses of PI-88 administered subcutaneously for 4 days per week, along with docetaxel 30 mg/m(2) given on days 1, 8, 15 of a 28-day schedule.
Results: Sixteen patients received a total of 42 courses of therapy.
New laboratory test in flow cytometry for the combined analysis of serologic and cellular parameters in the diagnosis of heparin-induced thrombocytopenia.
Cytometry B Clin Cytom
March 2004
Department of Anatomy, Human Anatomy Section, University of Parma, Parma, Italy.
Background: Heparin-induced thrombocytopenia (HIT) is a major complication of heparin therapy. A quick and reliable laboratory assay for the combined determination of pathogenic anti-heparin and platelet factor 4 (H:PF4) antibodies in the serum and platelet activation is not currently available.
Methods: We developed a new single-tube assay in flow cytometry that combines the detection of antibodies in the serum and their activatory properties on platelets.
A clinical study to assess the effect of heparin in dialyzer rinsing solutions.
Int J Artif Organs
February 1997
1st Department of Internal Medicine, Charles University School of Medicine, Pilsen, Czech Republic.
The solution usually recommended for rinsing the blood side, which is an indispensable step in preparing a dialyzer for hemodialysis (HD), contains saline and heparin. The heparin used for rinsing is said to reduce the thrombogenic properties of the dialysis membrane and, hence, also the need for systemic heparinization during the whole procedure. The aim of our study was to establish whether this postulate also applies to polysulphone steam-sterilized dialyzers.
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