Similar Publications
Noninvasive molecular imaging using anti-Trop-2 aptamer for targeted therapy of small cell lung cancer.
J Nanobiotechnology
March 2025
Institute of Molecular Medicine (IMM), Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, China.
Recent advancements in antibody-drug conjugates (ADCs) targeting trophoblast surface cell antigen 2 (Trop-2) have brought important progress in the field of targeted therapy. This progress also holds promise for the treatment of small cell lung cancer (SCLC) as anti-Trop-2 therapy appears to have a safe and effective clinical activity in metastatic SCLC patients. However, effective treatments of anti-Trop-2 ADCs rely on the comprehensive assessment of Trop-2 expression at the tumor sites, SCLC exhibits intratumoral heterogeneity, making the accurate acquisition of histological biopsies a challenge.
View Article and Find Full Text PDFPostpartum choriocarcinoma complicated by uterine perforation: A case report and literature review.
Case Rep Womens Health
March 2025
Al Quds University Faculty of Medicine, Jerusalem, Palestine.
Choriocarcinoma is a rare, aggressive gestational trophoblastic disorder with metastatic potential, often presenting with abnormal bleeding and increasing levels of beta-human chorionic gonadotropin (b-hCG). Diagnosis is confirmed through histopathologic examination after curettage, and treatment typically involves stage-dependent chemotherapy. This case report concerns a 25-year-old woman with heavy postpartum bleeding, later diagnosed with choriocarcinoma.
View Article and Find Full Text PDFFactors influencing serum hCG negativization timing in gestational trophoblastic neoplasia.
Am J Cancer Res
January 2025
Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310003, Zhejiang, China.
Gestational trophoblastic neoplasia (GTN) refers to malignant diseases originating from placental trophoblast cells. Despite high complete remission rates with standard treatments, the adverse effects of chemotherapy, variation in treatment regimens, and the psychological impact on patients significantly influence the prognosis. This study aims to identify factors influencing the time to serum human chorionic gonadotropin (hCG) negativization, thereby contributing to the optimization of patient management strategies.
View Article and Find Full Text PDFPulmonary trophoblastic deportation in the hystricomorph rodent Lagostomus maximus.
Placenta
February 2025
Laboratorio de Histología y Embriología Descriptiva, Experimental y Comparada, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina; Consejo Nacional de Investigaciones Científicas (CONICET), La Plata, Argentina. Electronic address:
Introduction: Trophoblast has been reported in the lungs of gestating eutherian mammals with hemochorial placenta, including humans, cotton rats, and American hares. This study describes the discovery of trophoblastic-like cells in the lungs of Lagostomus maximus.
Methods: Lung and placenta samples from non-pregnant and pregnant plains viscachas were analyzed using histology and immunohistochemistry.
Forensic considerations in nonthrombotic pulmonary embolism: A case report and review.
Med Sci Law
February 2025
School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.
Nonthrombotic pulmonary embolism is defined as the partial or total occlusion of the pulmonary circulation by various nonthrombotic agents, such as biological, nonbiological and foreign body material. A case is reported of lethal embolism of fragments of a renal calculus: A 64-year-old woman collapsed and died following laser lithotripsy. At autopsy calculous debris was found in the calyces of the right kidney with widespread microscopic fragments of birefringent foreign material in keeping with renal calculus within the pulmonary arterioles.
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