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Assessing sub-Saharan Africa's GHG emissions from croplands: environmental impacts and sustainable mitigation strategies.
Environ Monit Assess
January 2025
Department of Environmental Management, Institute of Environmental Engineering, RUDN University, Miklukho-Maklaya Street, 117198, Moscow, Russia.
Globally, agricultural lands are among the top emitters of greenhouse gases (GHGs), responsible for over 20% of total greenhouse gas (GHG) emissions. Climatic conditions, an acute challenge in sub-Saharan Africa (SSA), where access to mitigation technologies remains limited, have heavily influenced these lands. This study explores GHG contributions from crop production and their devastating and deteriorating impacts on the economy and environment and proposes a sustainable solution.
View Article and Find Full Text PDFRapid and Sensitive Detection of Mutations in SARS-CoV-2 by Surface-Enhanced Raman Spectroscopy.
Langmuir
January 2025
Shanghai Institute of Doping Analyses, Shanghai University of Sport, Shanghai 200438, PR China.
Since the outbreak of the novel coronavirus (SARS-CoV-2), the world has suffered significant losses. At present, the pneumonia disease caused by SARS-CoV-2 virus has not been eliminated, and SARS-CoV-2 has a high mutation rate, and its variant strains also have a high prevalence rate, which has always threatened the health of all mankind. This study aims to develop a rapid and sensitive method to complement existing SARS-CoV-2 diagnostic tools by utilizing surface-enhanced Raman spectroscopy (SERS) for the direct detection of the intrinsic SERS signal from the S proteins of SARS-CoV-2 and its variants (Omicron and Delta) within 5 min using a portable Raman spectrometer.
View Article and Find Full Text PDFPharmacokinetics and absorption, distribution, metabolism and excretion profiling of tanimilast following an intravenous C-microtracer coadministered with an inhaled dose in healthy male individuals.
Drug Metab Dispos
January 2025
Global Clinical Development, Chiesi Farmaceutici SpA, Parma, Italy.
Tanimilast is an inhaled phosphodiesterase-4 inhibitor currently in phase III clinical development for treating chronic obstructive pulmonary disease and asthma. This trial aimed to characterize the pharmacokinetics, mass balance, and metabolite profiling of tanimilast. Eight healthy male volunteers received a single dose of nonradiolabeled tanimilast via powder inhaler (Chiesi NEXThaler [3200 μg]), followed by a concomitant intravenous infusion of a microtracer ([C]-tanimilast: 18.
View Article and Find Full Text PDFHeterotropic allosteric modulation of CYP3A4 in vitro by progesterone: Evidence for improvement in prediction of time-dependent inhibition for macrolides.
Drug Metab Dispos
January 2025
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana.
Predictions of drug-drug interactions resulting from time-dependent inhibition (TDI) of CYP3A4 have consistently overestimated or mispredicted (ie, false positives) the interaction that is observed in vivo. Recent findings demonstrated that the presence of the allosteric modulator progesterone (PGS) in the in vitro assay could alter the in vitro kinetics of CYP3A4 TDI with inhibitors that interact with the heme moiety, such as metabolic-intermediate complex forming inhibitors. The impact of the presence of 100 μM PGS on the TDI of molecules in the class of macrolides typically associated with metabolic-intermediate complex formation was investigated.
View Article and Find Full Text PDFMOF-derived FeCe@Carbon catalysts for the efficient tetracycline degradation by activated persulfate: Preparation and mechanistic study.
J Colloid Interface Sci
January 2025
College of Resources and Environmental Engineering, Wuhan University of Science and Technology, Wuhan 430081 China.
Metal-organic frameworks (MOFs) derived materials are extensively utilized in wastewater treatment owing to their remarkable catalytic efficacy and durability. This study exploited iron-cerium-based bimetallic metal-organic framework (FeCe-MOF) as a sacrificial template, which was subsequently calcined at 700 °C to produce an iron-cerium-based bimetallic carbon nanospheres (FeCe@C). The FeCe@C has active sites of bimetallic Fe and Ce derivatives, demonstrating exceptional activation efficiency for persulfate, resulting in approximately 98.
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