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Stress antecedents and immune status in recently diagnosed type I (insulindependent) diabetes mellitus.
Diabete Metab
July 1989
Department of Diabetology, University of Marseille, France.
It has been speculated that stressful life events can precipate some autoimmune diseases by altering the immune system. This study was undertaken to test this hypothesis in type I (insulindependent) diabetes. Thirty-two young patients (less than 40 years) with a recently diagnosed IDDM and 53 age-matched controls were interviewed according to a standardized questionnaire designed to identify, date, and weigh past stressful life events.
View Article and Find Full Text PDFMany observations suggest that auto-immune process are activated during the beta-cell destruction in insulin-dependent diabetes (IDD): they include association with organ specific auto-immune disease, frequency of circulating anti-organ antibodies, circulating anti-islet cell antibodies, insulitis-like lesions in the pancreas and in vitro lymphocytic reaction against pancreatic antigens. However, it is still uncertain if these reactions are actually involved in the beta cell destruction. Cytotoxicity experiments on beta cells in culture and animal models support this hypothesis.
View Article and Find Full Text PDF[Immunological study of primary non-obstructive myocardiopathies. A report on 37 cases (author's transl)].
Ann Med Interne (Paris)
September 1980
The pathogenicity of primary non-obstructive myocardiopathies remains unknown at the present time. Immunological disturbances have been demonstrated but their role is open to discussion. A comparison between 37 such patients and 37 control subjects with cardiac insufficiency, similar according to age and sex, gave the following results: circulating immune complexes levels, anti-organ or anti-tissue antibody levels, and the levels of serum complement and its fractions were the same in both groups.
View Article and Find Full Text PDF[Anti-organ antibodies in pregnancy complicated by immunologic factors].
Zh Mikrobiol Epidemiol Immunobiol
March 1971
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