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[18F]Tetrafluoroborate: a new NIS PET/CT radiopharmaceutical. An overview focused on differentiated thyroid cancer.

Eur Thyroid J

January 2025

G Treglia, Repubblica e Cantone Ticino Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

Background: In relapsing differentiated thyroid cancer (DTC), the in vivo evaluation of natrium-iodine symporter (NIS) expression is pivotal in the therapeutic planning and is achieved by [131/123I]Iodine whole-body scan. However, these approaches have low sensitivity due to the low sensitivity due to the low resolution of SPECT. [18F]Tetrafluoroborate (TFB) has been proposed as a viable alternative, which could outperform [131/123I]Iodine scans owing to the superior PET resolution.

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Role of Pyroptosis in IVIG-Resistant Kawasaki Disease and the Establishment of a New Predictive Model.

J Inflamm Res

December 2024

Department of Pediatric Immunology, Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People's Republic of China.

Background: Intravenous immunoglobulin (IVIG) resistance may be an increased risk of coronary artery lesions which is the serious complication of Kawasaki disease (KD). Early and accurate identification of IVIG-resistant patients has an important clinical value.

Objective: To establish a new predicting model by detecting the pyroptosis markers with other clinical indicators.

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Article Synopsis
  • - The study used a scanning electron microscope with energy dispersive X-ray analysis to examine the elemental composition of the leaves of two plant species, Vaccinium myrtillus and Vaccinium vitis-idaea, from both clean and polluted areas.
  • - Results showed that the mine-polluted soil had higher levels of 11 elements, leading to significant changes in the leaves, particularly increased contents of certain elements in V. myrtillus, while V. vitis-idaea experienced decreased levels in most elements.
  • - The environmental impact also affected the production of phytochemicals, with V. myrtillus showing increased flavonoid levels while V. vitis-idaea saw a significant decrease, highlighting the importance of knowing
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Article Synopsis
  • * A study involving 268 AGC patients showed that those with hyponatremia had shorter progression-free survival (PFS) and overall survival (OS) compared to those with normal sodium levels.
  • * Serum sodium levels emerged as a potential independent prognostic factor for both PFS and OS, suggesting that monitoring sodium may help predict patient outcomes, though more extensive studies are needed to confirm these findings.
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