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Prednisolone pharmacokinetics in dogs with protein-losing enteropathy.
J Vet Intern Med
December 2024
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Background: It is unknown if glucocorticoid malabsorption contributes to the approximate 50% treatment failure rate in dogs with protein-losing enteropathy (PLE).
Objective: To compare pharmacokinetics (PK) of orally administered prednisolone in dogs with PLE vs healthy controls.
Animals: Fourteen dogs with well-characterized PLE and 7 control dogs.
Protein-losing enteropathy with congenital kidney stones in a 2-month-old boy: a rare case report and literature review.
BMC Med Genomics
November 2024
Department of Gastroenterology, Kunming Children's Hospital, Kunming, 650000, China.
Background: Protein-losing enteropathy (PLE) is a rare condition featured by severe loss of proteins through the gastrointestinal tract. Rare PLE cases complicated with congenital kidney stones have been reported. This case study aimed to illustrate our experiences on the diagnosis and treatment of PLE and congenital kidney stones in a neonate.
View Article and Find Full Text PDFCronkhite-Canada syndrome: A case report and literature review.
Medicine (Baltimore)
October 2024
Department of Gastroenterology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Article Synopsis
- Cronkhite-Canada syndrome (CCS) is a rare, nonhereditary condition characterized by gastrointestinal polyps, ectodermal changes, and symptoms such as hair loss, skin pigmentation, and malnutrition, predominantly affecting middle-aged and older males.* -
- The case study involves a 72-year-old female who experienced severe gastrointestinal issues, which led to the discovery of multiple polyps through endoscopic examinations after her treatment for intestinal obstruction.* -
- Following a comprehensive treatment plan that included medications and nutritional support, the patient showed significant improvement in symptoms, with reduced diarrhea and a notable decrease in the number and size of polyps upon follow-up examination.*
Systematic review of treatments for the gastrointestinal manifestations of systemic lupus erythematosus.
Semin Arthritis Rheum
December 2024
The University of Sydney, Australia; Royal Prince Alfred Hospital, Sydney, Australia. Electronic address:
Article Synopsis
- * A thorough literature search was conducted, analyzing 29 studies involving 767 patients, focusing on various gastrointestinal problems associated with SLE and their treatments.
- * The findings indicate that while treatments like intravenous methylprednisolone and oral prednisolone may benefit patients, the overall quality of evidence is low, emphasizing the necessity for better-defined disease standards and more robust clinical trials.
Lymphatic Imaging and Intervention in Central Lymphatic Disorders.
Lymphology
October 2024
Division of Cardiology, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
Advances in lymphatic imaging for both diagnosis and intervention are reviewed, and specific examples given for protein-losing enteropathy, multi compartment lymphatic failure, congestive heart failure. Presented at the 2023 ISL International Congress of Lymphology, Genoa, Italy in a special symposium on central and regional lymphatic system in health and disease.
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